糖尿病肾病患者尿白蛋白排泄率与肾功能、炎症反应、氧化应激反应的相关性  

Correlation of urinary albumin excretion rate with renal function,inflammatory response and oxidative stress response in patients with diabetic nephropathy

作　　者：饶毅峰[1] 杨林[1] 杜京涛[1] 朱平[1] 何川鄂[1] 宋志霞[1] 贾中尉[1] 

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院肾病内科,湖北宜昌443003

出　　处：《海南医学院学报》2017年第6期769-772,共4页Journal of Hainan Medical University

基　　金：三峡大学培优基金(A2011-302-23)~~

摘　　要：目的:探讨糖尿病肾病(DN)患者尿白蛋白排泄率与肾功能、炎症反应、氧化应激反应的相关性。方法:收集本院收治的DN患者78例,根据DN分级标准分为早期糖尿病肾病组51例、中晚期糖尿病肾病组27例;另取同期在本院进行体检的肾功能正常者60例作为正常对照组。入院即刻,测定各组研究对象的尿白蛋白排泄率(UAER);采用全自动生化分析仪测定肾功能指标含量,采用ELISA法测定炎症因子含量,采用放射免疫法测定氧化应激指标含量;采用Pearson检验分析DN患者UAER值与肾功能、炎症反应、氧化应激反应的相关性。结果:三组研究对象的UAER值,肾功能指标、炎症反应指标、氧化应激指标含量差异有统计学意义。早期DN组、中晚期DN组的UAER值以及BUN、Scr、CysC、β2-MG、IL-6、hs-CRP、TNF-α、MDA、AOPP含量高于正常对照组,T-AOC、SOD含量低于正常对照组;中晚期DN组的UAER值以及BUN、Scr、CysC、β2-MG、IL-6、hs-CRP、TNF-α、MDA、AOPP含量高于早期DN组,T-AOC、SOD含量低于早期DN组;DN患者的UAER值与肾功能、炎症反应、氧化应激呈相关关系(P<0.05)。结论:UAER值可直观反映DN患者的肾功能损伤、炎症反应及氧化应激程度,作为疾病早期诊断、治疗指导的可靠手段。Objective： To study the correlation of urinary albumin excretion rate with renal function, inflammatory response and oxidative stress response in patients with diabetic nephropathy （DN）. Methods： A total of 78 patients with DN treated in our hospital December 2012 and March 2016 were collected and divided into early diabetic nephropathy group （n = 51） and middle-advanced diabetic nephropathy group （n = 27） according to the DN grading standard; 60 subjects with normal renal function who received physical examination in our hospital during the same period were selected as normal control group. Immediately after admission, the urinary albumin excretion rate （UAER） of all groups were determined; automatic biochemical analyzer was used to determine renal function index levels, ELISA method was used to determine inflammatory factor levels,and RIA method was used to determine the oxidative stress index levels; Pearson test was used to analyze the correlation of UAER value with renal function, inflammatory response and oxidative stress response in patients with DN. Results： Differences in UAER value as well as renal function index, inflammatory response index and oxidative stress index levels were statistically significant among three groups of subjects. UAER value as well as BUN, Scr, CysC, 132-MG, IL-6, hs-CRP, TNF-α, MDA and AOPP levels of early DN group and middle-advanced DN group were higher than those of normal control group while T- AOC and SOD levels were lower than those of normal control group; UAER value as well as BUN, Scr, CysC, β2-MG, IL-6, hs-CRP, TNF-α, MDA and AOPP levels of middle-advanced DN group was higher than those of early DN group while T-AOC and SOD levels were lower than those of early DN group; UAER value in patients with DN was correlated with renal function, inflammatory response and oxidative stress （P〈0.05）. Conclusion： UAER value can directly reflect the renal injury, inflammation and oxidative stress in patients with DN, and be the reliable means for ear

关 键 词：糖尿病肾病 尿白蛋白排泄率 肾功能 炎症反应 氧化应激反应 

分 类 号：R587.2[医药卫生—内分泌]