骨骼肌缺血再灌注的病理生理研究进展  

Research advances in the pathophysiological changes in skeletal muscle ischemia-reperfusion

作　　者：龚永良 闫浩[1] 李颖[1] 

机构地区：[1]解放军第四五四医院骨科,江苏南京210002

出　　处：《解放军医学院学报》2017年第3期284-286,共3页Academic Journal of Chinese PLA Medical School

基　　金：部委级资助项目;南京军区十二五计划课题项目(12MA043)~~

摘　　要：外周血管病(peripheral arterial disease,PAD)是一类常见的下肢循环系统疾病,其过程中发生的缺血再灌注是组织氧供不足、线粒体病、自由基产生和炎症发生的重要原因,同时也是骨骼肌坏死和远隔器官损伤的主要原因。本文将对骨骼肌细胞缺血再灌注损伤后的病理生理变化作一简要综述,为认识骨骼肌缺血再灌注发生发展的过程,同时也为寻找新的治疗方法提供新思路。Peripheral arterial disease （PAD） is a common circulatory disorder of the lower limb arteries that reduces patient＇ s functional capacity and life quality. Despite relatively effective available treatments, PAD is a serious public health issue associated with a significant morbidity and mortality. Ischemia-reperfusion cycles occurring during PAD are responsible for insufficient oxygen supply, mitochondriopathy, free radical production, inflammation and lead to events that contribute to myocyte death and remote organ failures. However, the pathophysiological changes that occur during the ischemic period and at the moment of reperfusion have been poorly reviewed in skeletal muscle fibers. Thus, we will discuss the physiopathology of ischemia and reperfusion from a mitochondrial and cellular levels. A better chronological understanding of the events underlying ischemia-reperfusion will allow us to identify key factors in the development of this pathology and provide new suitable therapies.

关 键 词：外周血管病 骨骼肌 缺血再灌注损伤 病理生理 

分 类 号：R337[医药卫生—人体生理学]