新型动脉僵硬度指标与中年早期动脉粥样硬化的相关性  

Correlation between new arterial stiffness indexes and early atherosclerosis in middle-aged population

作　　者：章亚平[1] 尹萍[1] 许左隽[1] 解玉水[1] 王长谦[1] 范虞琪[1] 梁夫友[2] 殷兆芳[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院心脏科,上海市200011 [2]上海交通大学-千叶大学国际合作研究中心

出　　处：《心血管康复医学杂志》2017年第2期121-124,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：国家自然科学基金(81370438)~~

摘　　要：目的:探讨动脉波速指数(AVI)和动脉压力容积指数(API)对中年人群的早期动脉粥样硬化的预测价值。方法:选择2016年5月至2016年11月于我院住院的138例中年患者,根据冠脉造影(CAG)检查结果,分为动脉粥样硬化(AS)组(86例)和非AS组(52例)。CAG之前采集两组AVI、API和肱-踝脉搏波速度(baPWV),比较两组一般资料和动脉僵硬度指标,并分析AVI、API、baPWV和一般资料的相关性。结果:与非AS组比较,AS组AVI[(20.4±4.2)比(22.8±5.3)]和baPWV[(14.0±2.5)m/s比(16.3±3.0)m/s]均显著升高(P均<0.01)。AVI与年龄、收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、脉压(PP)、API和baPWV呈显著正相关(r=0.219~0.471,P<0.05或<0.01);API与年龄、人体质量指数(BMI)、SBP、DBP、MAP、PP、脑钠肽(BNP)、AVI和baPWV呈显著正相关(r=0.213~0.726,P<0.05或<0.01);baPWV与年龄、BMI、SBP、DBP、MAP、PP、AVI和API呈显著正相关(r=0.201~0.472,P<0.05或<0.01)。多元线性回归分析显示SBP是AVI的影响因素(B=0.162,P=0.001),SBP、DBP和HDL-C是API的影响因素(B=-0.166~2.146,P<0.05或<0.01),SBP和HDL-C是baPWV的影响因素(B=0.116,-3.009,P均<0.01)。结论:升高的AVI和baPWV均可预测中年的动脉粥样硬化。Objective：To explore predictive value of arterial velocity-pulse index（AVI）and arterial pressure-volume index（API）for early atherosclerosis（AS）in middle-aged population.Methods：A total of 138middle-aged patients hospitalized in our hospital from May 2016 to Nov 2016 were enrolled.According to coronary angiography（CAG）outcomes,they were divided into AS group（n=86）and non-AS group（n=52）.Before CAG,AVI,API and brachial-ankle pulse wave velocity（baPWV）were collected in two groups.General data and arterial stiffness indexes were compared between two groups,and the correlation among AVI,API,baPWV and general data were analyzed.Results：Compared with non-AS group,there were significant rise in AVI[（20.4±4.2）vs.（22.8±5.3）]and baPWV [（14.0±2.5）m/s vs.（16.3±3.0）m/s]in AS group,P〈0.01 both.AVI was significant positively correlated with age,SBP,DBP,mean arterial pressure（MAP）,pulse pressure（PP）,API and baPWV（r=0.219-0.471,P〈0.05or0.01）;API was significant positively correlated with age,BMI,SBP,DBP,MAP,PP,brain natriuretic peptide（BNP）,AVI and baPWV（r=0.213-0.726,P〈0.05or0.01）;baPWV was significant positively correlated with age,BMI,SBP,DBP,MAP,PP,AVI and API（r=0.201-0.472,P〈0.05or0.01）.Multi-factor linear regression analysis indicated that SBP was influencing factor for AVI（B=0.162,P=0.001）,SBP,DBP and HDL-C were influencing factors for API（B=-0.166-2.146,P〈0.05or0.01）,SBP and HDL-C were influencing factors for baPWV（B=0.116,-3.009,P〈0.01both）.Conclusion：Both elevated AVI and baPWV can predict atherosclerosis in middle-aged population.

关 键 词：动脉硬化 冠心病 脉搏 

分 类 号：R541.409[医药卫生—心血管疾病]