磁性四氧化三铁纳米粒子在医学诊疗领域的研究  

Research on magnetic iron oxide nanoparticles for theranostics

作　　者：严微[1] 郭娇娇 向晨阳 莫康伟 徐祖顺[1] 

机构地区：[1]功能材料绿色制备与应用教育部重点实验室,有机化工新材料湖北省协同创新中心,湖北大学材料科学与工程学院,湖北武汉430062

出　　处：《湖北大学学报（自然科学版）》2017年第3期317-322,328,共7页Journal of Hubei University：Natural Science

基　　金：湖北省教育厅科研项目(Q20141006)资助

摘　　要：在过去的几十年间,纳米粒子在生物医学领域取得了飞速发展.在众多类型的纳米粒子中,磁性四氧化三铁(Fe_3O_4)纳米粒子又以其大比表面积、低毒性和良好的生物相容性等物理化学性质而得到全世界生物医用领域的广泛关注.配合以表面修饰手段以及相应的体内作用机制,磁性四氧化三铁(Fe_3O_4)纳米粒子展现出巨大的应用价值,已成为在生物医学材料领域应用最为成功的磁性纳米粒子之一.文中概述了Fe_3O_4纳米粒子作为诊断试剂、药物载体以及诊疗一体化试剂的研究进展,并对该领域的未来发展进行展望.In the past few decades,there has been rapid progress in the research of nanoparticles inbiomedicine field.Among the various of nanoparticles,magnetic iron oxide(Fe_3O_4) nanoparticles haveattracted much attention in the world due to their large surface area,low toxicity and excellentbiocompatibility.With the surface modification and the corresponding behavior in vivo,magnetite(Fe_3O_4)nanoparticles show great application values,which has become one of the most successful use of magneticnanoparticles in biomedical applications.We briefly summarized the present progress of the research of Fe_3O_4 nanoparticles used as the diagnostic reagents,drug carrier and theranostic reagents,and gave an outlook aboutthe future of magnetic iron oxide.

关 键 词：磁性FE3O4纳米粒子 诊疗试剂 药物载体 诊疗一体化试剂 

分 类 号：R318.08[医药卫生—生物医学工程]