RuCl_3·3H_2O/TMEDA体系催化空气对苄醇的氧化性研究  

Oxidation of Benzyl Alcohols Using RuCl_3·3H_2O-TMEDA in Air

作　　者：彭海燕 曾繁荣 刘良先[2] 范卫永 

机构地区：[1]江西青峰药业有限公司技术中心,江西赣州341000 [2]赣南师范大学化学化工学院,江西赣州341000

出　　处：《江西化工》2017年第2期58-60,共3页Jiangxi Chemical Industry

摘　　要：对RuCl_3·3H_2O/TMEDA催化空气氧化苄醇的反应进行了研究,结果表明在RuCl_3·3H_2O/TMEDA催化下,苄醇被有效的氧化成相应的醛,具有较高的反应收率,条件温和,操作简便,等特点。RuCl_3·3H_2O/TMEDA催化氧化苄醇实验过程:1.0 mmol苄醇溶液,0.05 mmol RuCl_3·3H_2O,加入1 ml THF,逐滴加入1.0 mmol TMEDA,室温下搅拌,TLC监测反应进程,反应结束,减压浓缩,粗品经硅胶柱层析提纯。The aerobic oxidation of benzylic alcohols to aldehydes was performed in a RuC13·3H2（ - tetramethylethylene- diamine（ TMEDA） catalyst system under air atmosphere at room temperature. The higher conversion, mild reaction condi-tions, and experimental ease of this transformation have made it a valuable alternative to current available methods. Typical Experimental Procedure for Oxidation of Benzylic Alcolols Using RuC1 3 ？ 3H20/TMEDA. To a solution of benzylic alcohol （1.0 mmol） and RuCl3·3H2O（0. 05 mmol） in THF（ 1 mL） was added dropwise TMEDA（ 1.0 mmol） under air atmosphere and the mixture was stirred at room temperature（monitored by TLC）. Then,the solvent was removed under reduced pressure and the crude product was purified by silica gel column chromatography to provide the desired product.

关 键 词：三氯化钌 四甲基乙二胺 苄醇 空气氧化 

分 类 号：TQ203.2[化学工程—有机化工]