仿真针刺对AA大鼠炎症局部β-内啡肽及POMC基因表达的影响  

Effects of simulation acupuncture on β-endorphin and POMC genetic expression in local Inflammatory of AA Rats

作　　者：王观涛[1] 杨华元[1] 李芳杰[1] 

机构地区：[1]上海中医药大学针灸推拿学院,上海201203

出　　处：《西北国防医学杂志》2017年第3期144-147,共4页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:从内源性阿片肽系统探索仿真针刺对佐剂性关节炎(AA)大鼠镇痛后效应的外周机制。方法:以AA大鼠为炎症疼痛模型,观察仿真针刺对外周内源性β-内啡肽(β-EP)系统的影响。结果:一次针刺治疗后,大鼠痛阈提高,β-EP含量及前阿黑皮素(POMC)基因转录水平升高,作用持续72h。结论:针刺镇痛后效应与炎症局部β-EP含量及POMC基因转录水平升高有关。Objective：To explore peripheral mechanisms of post-effect of acupuncture analgesia by simulation acupuncture in AA rats from endogenous opioid system.Methods：The impact of foreign-derived β-endorphin（β-EP）system were observed by inflammatory pain models of AA rats.Results：The pain threshold,β-EP content and genetic expression of pro-opiomelanocortin（POMC） mRNA increased,which lasted 72 hours,after one acupuncture treatment.Conclusion：The post-effect of acupuncture analgesia associated with β-EP content and genetic expression of POMC mRNA increased in inflammatory topical.

关 键 词：仿真针刺 镇痛后效应 Β-内啡肽 前阿黑皮素 基因表达 

分 类 号：R245[医药卫生—针灸推拿学]