白细胞免疫球蛋白样受体A2基因多态性与上海地区汉族系统性红斑狼疮相关性的研究  

Study of the association of gene polymorphism of leukocyte immunoglobulin-like receptors A2 (LILRA2) with systemic lupus erythematosus in Han populations in Shanghai

作　　者：李星军[1] 张瑜芬 李锋[2] 李书娟[2] 郑伊安 黄岚[2] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院检验科,上海202150 [2]复旦大学附属华山医院皮肤科,上海200040

出　　处：《临床皮肤科杂志》2017年第5期318-321,共4页Journal of Clinical Dermatology

摘　　要：目的:检测系统性红斑狼疮(SLE)患者LILRA2基因多态性位点(rs2241524)的基因型频率,探讨其与SLE易感性的相关性。方法:采用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)对SLE患者组(230例)及对照组(260例)LILRA2基因rs2241524位点进行基因分型。结果:SLE患者组LILRA2(rs2241524)基因型AA频率(6.5%)高于对照组(1.9%),差异有统计学意义(P<0.05);基因型AG频率(36.1%)和GG频率(57.4%)分别与对照组(34.6%、63.5%)比较,差异均无统计学意义(P均>0.05);SLE患者组等位基因A基因频率(24.6%)高于对照组(19.2%),差异有统计学意义(P<0.05)。结论:上海地区汉族LILRA2基因多态性位点rs2241524(G>A)与SLE发生相关。Objective： To investigate the correlation between LILRA2 gene polymorphism （rs2241524） and susceptibility of systemic lupus erythematosus（SLE）. Methods： DNA samples from controls（260 cases） and SLE patients（230 cases） were genotyped using matrix assisted laser desorption/ionization time of flight mass spectromeh7. Results： The polymorphism rs2241524 genotype frequency of AA was higher in SLE than in the controls（6.5% vs. 1.9%, P〈0.05）. Genotype frequencies of AG and GG were no significant differences between SLE （36.1%, 57.4%） and the controls（34.6%, 63.5%）. The frequency of allele A was also significantly higher in SLE than in the controls（24.6% vs. 19.2%, P〈0.05）. Conclusion： The polymorphism of LILRA2 （rs2241524 G〉A） is associated with the development of SLE in Han population in Shanghai.

关 键 词：白细胞免疫球蛋白样受体 系统性红斑狼疮 基因多态性 基因型 

分 类 号：R593.24[医药卫生—内科学]