氟比洛芬酯用于老年急腹症围术期超前镇痛40例  

Flurbiprofen Ester Used in Perioperative Analgesia on 40 Cases of Senile Acute Abdomen Patients

作　　者：章静[1] 徐家济[1] 宋凯[2] 范宝玉 

机构地区：[1]北京丰台右安门医院麻醉科,北京100069 [2]天津市黄河医院麻醉科,天津300110 [3]北京朝阳急诊抢救中心,北京100027

出　　处：《中国中西医结合外科杂志》2017年第2期147-150,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:观察氟比洛芬酯超前镇痛用于老年急腹症围术期超前镇痛的效果及安全性。方法:急腹症手术患者80例随机分为两组,A组于麻醉诱导前30 min缓慢静脉注射凯纷1 mg/kg,B组手术切皮时给予同等剂量的凯纷,观察术后1 h、2 h、6 h视觉模拟量表(VAS)镇痛评分、镇静评分、循环、呼吸、血氧饱和度、BIS及不良反应发生情况。结果:术中瑞芬太尼用量:A组(2.1±0.9)mg,B组(3.8±0.7)mg,两组存在统计学差异(P<0.05),术中依托咪酯用量:A组(40±6.6)mg,B组(60±5.4)mg,两组存在统计学差异(P<0.05)。用量术后1 h、2 h和6 h的VAS镇痛评分及疼痛干预次数两组存在统计学差异(P<0.05)。术后镇静评分两组无统计学差异(P>0.05),术后均无过度镇静、恶心呕吐等不良反应。结论:氟比洛芬酯超前镇痛效果确切,可降低术中镇痛药的用量,能有效缓解急腹症老年患者术后疼痛,无明显不良反应。Objective To observe the effect and the safty of the flurbiprofen ester perioperative analgesia in advance for senile acute abdomen patients.Methods Eighty senile acute abdomen patients were divided into two groups randomly.The group A was given flurbiprofen ester 30 minutes before the surgery with 1mg/kg at a slow pace.The group B was given flurbiprofen ester at the same speed and equal dose until skin incision.The differences on visual analog scale（VAS）pain scores,sedation scores,circulation,respiration,blood oxygen saturation,the BIS and adverse reactions during 1 hour,2 hours and 6 hours after the operation were evaluated.Results In group A the remifentanil intraoperative dosage was（2.1±0.9）mg,but in group B the dosage was（3.8±0.7）mg with statistical differences between the two groups（P〈0.05）.About etomidate intraoperative usage,it was（40±6.6）mg in group A,but it was（60±5.4）mg in group B.There were the significant differences between the two groups on the VAS pain scores and the numbers of pain intervention dosage after the operation in 1 hour,2 hour and 6 hours（P〈0.05）.In postoperative sedation scores there were no differences between the two groups（P〉0.05）.No postoperative adverse reactions of excessive sedation,nausea or vomiting occurred.Conclusion Flurbiprofen ester has exact analgesic effect.It can reduce the use of intraoperative analgesia drug dose,and may effectively relieve postoperative pain on the senile acute abdomen patients with no obvious adverse reactions.

关 键 词：氟比洛芬酯 超前镇痛 地佐辛 老年急腹症 

分 类 号：R971.1[医药卫生—药品]