HNL、PCT及CRP在急性细菌感染中的诊断价值研究  

Diagnostic value of human neutrophil lipocalin,procalcitonin,CRP in acute bacterial infection

作　　者：郭靓[1] 朱菁薇 王占科[2] 周媛[2] 邓伦志 

机构地区：[1]中国人民解放军第九四医院检验科,江西南昌330002 [2]第三军医大学附属第一医院检验科,重庆400038

出　　处：《检验医学与临床》2017年第8期1133-1135,共3页Laboratory Medicine and Clinic

摘　　要：目的研究中性粒细胞载脂蛋白(HNL)、降钙素原(PCT)及C反应蛋白(CRP)在急性细菌感染中的诊断价值。方法选取2015年6-12月间住院急性感染性疾病患者350例,其中细菌性感染的患者184例(细菌组)、病毒性感染的患者166例(病毒组)。选取同期接受健康体格检查的职工或在校学生作为对照组,共155例。根据酶联免疫法、双抗体夹心层析、免疫比浊法等原理分别定量检测所有人员血清中HNL、PCT及CRP值,并分析其实际诊断价值。结果发现细菌组PCT、HNL及CRP分别为(2.41±1.23)ng/mL、(232.54±101.23)ng/mL及(55.14±38.47)mg/L,均显著高于病毒组及对照组水平,且检测出的HNL水平升高最为显著,差异有统计学意义(P<0.05)。同时发现细菌组PCT、HNL及CRP的阳性率分别为82.06%、94.02%及70.65%,远远超出病毒组和对照组,且HNL的阳性率最高,差异有统计学意义(P<0.05)。而后2组间比较,差异无统计学意义(P>0.05)。结论 HNL、PCT及CRP对细菌感染较为敏感,鉴别诊断能力较强,其中以HNL升高最为显著,特异性强、准确率高,可为早期诊断提供重要参考依据。Objective To study the diagnostic value of human neutrophil lipocalin（HNL）,procalcitonin（PCT）and CRP in acute bacterial infection.Methods Three hundreds and fifty inpatients with acute infectious diseases in the hospital from June 2015 to December 2015 were selected,including 184 cases of bacterial infection（bacterial group）and 166 cases of viral infection（viral group）.Contemporaneous 155 staffs receiving the healthy physical examination or enrolled students were chosen as the control group.Serum HNL,PCT and CRP values in all subjects were detected by using ELISA,double antibody sandwich chromatography and immunoturbidimetry.Results The levels of PCT,HNL and CRP in the bacterial group were（2.41±1.23）ng/mL,（232.54±101.23）ng/mL and（55.14±38.47）mg/L respectively,which were significantly higher than those in the viral group and the control group,moreover the increase of detected HCL level was most obvious,the difference was statistically significant（P〈0.05）.At the same time the positive rates of PCT,HNL and CRP in the bacterial infection group were 82.06%,94.02%and 70.65%respectively,which were far out of those in the viral group and control group,the difference was statistically significant（P〈0.05）,but the difference between the latter two groups had no statistical difference（P〈0.05）.Conclusion HNL,PCT and CRP are more sensitive to bacterial infection,which have a strong differential diagnosis capacity,in which the NHL increase is most significant with strong specificity and high accuracy,and can provide an important reference basis for the early diagnosis.

关 键 词：中性粒细胞载脂蛋白 降钙素原 C反应蛋白 急性细菌感染 诊断价值 

分 类 号：R978.1[医药卫生—药品]