普罗布考微囊的制备与性质考察  

Preparation and Properties Study of probucol microcapsules

作　　者：杨晓艳[1] 张爱武[1] 

机构地区：[1]武汉科技大学附属天佑医院,武汉430064

出　　处：《北方药学》2017年第4期156-158,共3页Journal of North Pharmacy

摘　　要：目的:研究普罗布考微囊的制备工艺,考察其体外释药特性。方法:用复凝聚法制备普罗布考微囊,以包封率为指标,用正交试验设计法对微囊的制备工艺进行研究,对其形态、体外释药特点等进行研究。结果:当囊心与囊材比为1∶3、搅拌速率为200r/min、成囊温度为60℃时,制得的普罗布考微囊囊形圆整光滑,囊壁清晰,粒径均匀,平均包封率可高达74.57%,载药量平均为17.93%,囊径为35~95μm,24h累积释药量93.61%。结论:制备的普罗布考微囊工艺简单、可靠,具有缓释效果。Objective ：To study the preparation technology of probucol microcapsules, then examine their in vitro release. Methods：The probueol mieroeapsules were prepared with the complex agglutination method. The preparation technique of probucol microcapsules was optimized by orthogonal design,afterwards its In vitro release of probucol microcapsules and morphology were studied. Results：The highest rate of production and minimum diameter of microeapsules were obtained when the ratio of coating material to probucol was 1：3, the temperature of encapsulation was 60~C , and the stirring speed was 200r/min. The obtained microcapsules were smooth round capsule-shaped, wall clear, uniform particle size, the average encapsulation rate up to 74.57%, the average drug loading 17.93%, and the microcapsule diameter 35-95txm,the accumulated release amount is 93.61% in 24h. Conclusion：To prepare probucol mierocapsules is simple and reliable, microcapsules could provide some controlled-release effect.

关 键 词：普罗布考 微囊 制备工艺 体外释放 

分 类 号：R943[医药卫生—药剂学]