小续命汤的物质基础、药理作用及临床应用研究进展  

Research Progress in Material Basis,Pharmacological Effect and Clinical Application of Xiao Xumingtang

作　　者：陈茜睿 胡亚[1] 杨志宏[1] 

机构地区：[1]中国医学科学院药用植物研究所,北京100193

出　　处：《中国实验方剂学杂志》2017年第9期214-220,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81273654;81473579;81102879);国家"重大新药创制"科技重大专项(2013ZX09103002-022)

摘　　要：系统地梳理和综述关于小续命汤的物质基础、药理作用及临床应用的相关研究,为此方面的深入研究工作提供参考。查阅近年来国内外文献,对资料进行分析整理和汇总。小续命汤方含有12味中药,组方相对复杂,在唐宋时期曾为治风之首剂,被古时医家尊为治疗中风的要剂,但宋朝以后小续命汤治疗卒中的地位不断下降,多被搁置不用。近年来发现小续命汤重新进入了医家和研究者的视线,且以"小续命汤有效成分组"作为物质基础进行该复方的药理、药代研究有了更深入的进展,表现为小续命汤能够恢复线粒体的氧化磷酸化水平、肿胀度及其损伤引发的凋亡程度,同时降低缺血性脑中风大鼠血清中一氧化氮合酶活性及一氧化氮含量。而小续命汤的药代动力学研究尚处于初步阶段,主要以单一成分的药动学研究为主,且在该领域的发展依赖于复方物质基础研究的高度。小续命汤不仅对中风及中风后遗症有明显的治疗作用,对于类风湿性关节炎、糖尿病等其他疾病也有一定疗效。因此,通过筛选、分析小续命汤物质成分基础,探讨其在体内的复杂变化及药理效应、临床应用具有重要意义,可更深入、更全面地认识为小续命汤,为其他中药复方的现代化研究工作提供参考。Xiao Xumingtang has been a traditional Chinese prescription for treating stroke since Tang and Song dynasty. However,it was silence for hundred of years due to some reasons. Now in recent years,it has been gradually regain. The chemical composition of Xiao Xumingtang is complex,and studies on its effective substance basis and pharmacological mechanism of anti-stroke are still in the preliminary stage of development. It is highly necessary to study and explore how to monitor the complex changes,confirm the action target and the biological effect of each component on the basis of screening and analysis of the effective components in Xiao Xumingtang. This article reviews and summarizes the research progress in material basis,pharmacological research and clinical application of Xiao Xumingtang in recent years, and provides references for the modernization prescription studies of Xiaoxuming Tang.

关 键 词：小续命汤 有效成分组 脑卒中 物质基础 药理作用 临床应用 

分 类 号：R285[医药卫生—中药学] R284[医药卫生—中医学]