中药复方对类风湿性关节炎干预机制的研究进展  

Research Progress on Chinese Herbal Compounds for Rheumatoid Arthritis

作　　者：熊江华[1] 李艳[2] 

机构地区：[1]皖南医学院,安徽芜湖241001 [2]皖南医学院附属弋矶山医院,安徽芜湖241001

出　　处：《中国实验方剂学杂志》2017年第9期230-234,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局重点学科中医痹病学建设项目(国中医药人教发[2012]32号);安徽省科技厅科技攻关项目(11010402173);安徽省卫生计生委中医药科研项目(2014zy27);皖南医学院重点科研项目培育基金项目

摘　　要：对近年报道的关于中药复方对类风湿性关节炎的干预机制研究方面的文献进行归纳分析。通过检索万方、中国知网等大型数据库及国外数据库,查阅近年来有关中药复方对类风湿性关节炎的干预机制研究方面的文献,发现中药复方对类风湿性关节炎干预机制主要涉及调控炎症因子水平、神经内分泌、免疫反应通路、基因表达等方面,通过多靶点系统的干预病理过程。目前研究表明中药复方可从多种途径干预类风湿性关节炎的病理过程,显示了中药复方治疗类风湿性关节炎的优势和前景,但如何运用中医理论准确辨证和精确配方仍有待探索。开展大样本采集和大数据挖掘,进行中药复方辨证论治机制研究将是发挥中西医结合的更有效的方法。The literature in recent years about the intervention mechanisms of Chinese herbal compounds for rheumatoid arthritis were summarized and analyzed in this paper. Wanfang,CNKI and other large Chinese databases and foreign databases were searched for the literature about the intervention mechanisms of Chinese herbal compounds for rheumatoid arthritis. The results showed that the intervention mechanisms of Chinese herbal compounds for rheumatoid arthritis were mainly through multiple-target system,referring to regulating inflammatory factor levels,neuroendocrine,immune response pathways and gene expression. The current researches indicate that Chinese herbal compounds can intervene the pathological process of rheumatoid arthritis in various methods,showing the great advantages and prospects of Chinese herbal compounds for rheumatoid arthritis; however,it remains to be explored about how to apply Chinese traditional dialectical theory for accurate syndrome differentiation and precise prescription. In addition,big-scale samples collection and data mining will become the more effective methods to accurately and precisely explore the syndrome differentiation mechanism for Chinese herbal compounds.

关 键 词：中药复方 类风湿性关节炎 干预机制 

分 类 号：R287[医药卫生—中药学]