线粒体脑肌病合并乳酸血症和卒中样发作的影像学表现  

The Imaging Manifestations of Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke

作　　者：龚霞蓉[1] 芮茂萍[1] 毕国力[1] 郭家智[2] 陈婧[1] 符浩[1] 边立功[2] 吴昆华[1] 

机构地区：[1]云南省第一人民医院,昆明理工大学医学院附属医院,云南昆明650032 [2]昆明医科大学基础医学院人体解剖学与组织胚胎学系,云南昆明650500

出　　处：《昆明医科大学学报》2017年第3期55-58,共4页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2013FB120;2014FB004);云南省教育厅科学研究基金资助项目(2014C009Y)

摘　　要：目的分析线粒体脑肌病患者的影像表现,以期为该病的诊断和临床治疗提供影像学依据.方法回顾性分析临床确诊的1例线粒体脑肌病患者的MRI表现,并结合文献报道,分析病变区血管影和基底节钙化.结果线粒体脑肌病合并乳酸血症和卒中样发作(mitochondrial encephalomyopathy with lactic acidosis and stroke,MELAS)好发于颞、枕、顶叶,表现为长T1、长T2信号,弥散像上呈高信号,ADC图上呈等及低信号,增强扫描无强化或脑回样强化,MRA上表现为病变区血管影增多,CT可表现为双侧基底节钙化.结论 MELAS的影像学表现具有一定特异性,但确诊仍需结合临床.Objective To investigate the imaging manifestations with mitochondrial encephalomyopathy （ME） and provide imaging evidences for the diagnosis and treatment of ME. Methods The imaging findings of a comfirmed case of MELAS were studied retrospectively. Results The lesions mainly located in the cerebral occipital lobe, temporal lobe, parietal lobe. All the lesions showed hypointense on Tl-weighted image and ADC map, hyperintense on T2-weighted image and diffusion weighted image （DWI） , and no enhancement. The artery increased in MRA. The appearances of CT images were the high intensity calcification in basal nuclei. Conclusion The imaging findings of MRLAS are useful for the diagnosis, but the confirmation should be combined with clinical situation.

关 键 词：线粒体脑肌病 磁共振 体层摄影术 

分 类 号：R445[医药卫生—影像医学与核医学]