链球菌毒力因子溶血素S的研究进展  

Research progress on the virulence factors of Streptococcus hemolysin S

作　　者：王虹[1] 彭爽[1] 陈德芳[1] 

机构地区：[1]四川农业大学动物科技学院水产系,温江611130

出　　处：《中国人兽共患病学报》2017年第3期287-292,共6页Chinese Journal of Zoonoses

基　　金：四川省教育厅项目(No.13ZB0279)资助~~

摘　　要：链球菌溶血素S(Streptolysin S,SLS)是链球菌产生的重要毒力因子之一。化脓链球菌、海豚链球菌、咽峡炎链球菌等多种人和动物致病性链球菌均含有该毒力因子,化脓链球菌是人类主要的病原菌,其致病机制备受关注。SLS是一个由sagA-sagI 9个连续基因编码修饰的多肽性细胞溶素,具有帮助致病菌渗透上皮屏障、造成组织损伤、抵抗宿主免疫细胞吞噬、与其他毒力因子相互作用的功能;SLS可作为细胞群体感应的信号分子,参与调节其他毒力因子的表达。本文对SLS的结构和在致病过程中的生物学功能作一综述。Streptolysin S （SLS）, one of the important virulence factors of Streptococcus, exist in several kinds of human and animal pathogenic bacterial, including Streptococcus pyogenes ,Strepstococcus iniae and Streptococcus anginosus. SLS is a peptide toxin encoded by nine consecutive genes （sagA-sagI）. The functions of SLS include contributing pathogenic bacterium to pass through epithelial barrier, causing tissue damage, resisting to phagocytic clearance of host immune cells and interacting with other virulence factors. In addition, SLS as a signaling molecule of cell quorum sensing is involved in regulating the expression with other virulence factors. This paper summarized the structures and the biological functions of SLS in Streptococcus infection.

关 键 词：化脓性链球菌 链球菌溶血素S 结构 致病作用 

分 类 号：R378.1[医药卫生—病原生物学]