金佛山雪胆的化学成分研究  

Chemical Constituents from the Tubers of Hemsleya penxianensis

作　　者：李叶丹[1,2] 孙晓波[2] 许旭东[2] 周兴杨 张洪洋[1] 王云卿[3] 代华年 杨峻山[2] 马国需[2] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨150076 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193 [3]广西师范学院化学与材料科学学院,南宁530001

出　　处：《中国药学杂志》2017年第8期627-630,共4页Chinese Pharmaceutical Journal

基　　金："重大新药创制"科技重大专项"十二五"计划(2012ZX09301002-001-033)

摘　　要：目的研究金佛山雪胆(Hemsleya penxianensis)的化学成分。方法采用柱色谱方法对金佛山雪胆体积分数95%甲醇提取物进行分离纯化,结合波谱技术与理化常数进行结构鉴定。结果从金佛山雪胆体积分数95%甲醇提取物中分离得到了5个化合物,分别鉴定为2β,3α,16α,20,24-pentahydroxycucurbita-5,25(E)-diene-11,22-dione(1)、雪胆甲素(2)、雪胆乙素(3)、巨花雪胆G(4)和jinfushanencins B(5)。结论化合物1为新化合物。OBJECTIVE To study the chemical constituents from the tubers of Hemsleya penxianensis. METHODS The constit- uents were isolated from the tubers of H. penxianensis and purified by column chromatography, and the structures were identified by spectral analysis and chemical methods. RESULTS Five compounds were isolated from the tubers of H. penxianensis and the struc- tures were identified as 213,3ct, 16α, 20, 24-pentahydroxycucurbita-5, 25 （E） -diene-11,22-dione （ 1 ）, cucurbitacin Ⅱa （ 2 ）, cucurbitacin Ⅱb （3） , hemslecins G（4）, and jinfushanencins B （5）. CONCLUSION Compound 1 is a new compound.

关 键 词：葫芦科 雪胆属 金佛山雪胆 三萜类化合物 雪胆素 

分 类 号：R284[医药卫生—中药学]