响应面设计试验法优化复方左旋肉碱涂膜剂的制剂处方  

Optimization of Formulation of Compound L-Carnitine Coating Agent by Response Surface Design Method

作　　者：何群[1] 李湘璐 王适[2] 吕毅 钟鸣[1] 杨崧[1] 

机构地区：[1]湖南中医药大学药学院 [2]湖南中医药大学第二临床医学院,长沙410005 [3]湖南食品药品职业学院,长沙410208

出　　处：《中国药学杂志》2017年第8期655-660,共6页Chinese Pharmaceutical Journal

基　　金：长沙市科技局计划项目(K0803123-21)

摘　　要：目的优化复方左旋肉碱涂膜剂的制剂处方,为工业化生产提供依据。方法以涂膜剂成膜时间为评价指标,在单因素试验的基础上,采用星点设计试验法优选成膜材料丙烯酸树脂Ⅱ及增塑剂甘油的最优配比。结果单因素试验及星点设计试验结果可知,涂膜剂成膜材料为15.4%丙烯酸树脂Ⅱ,增塑剂为10.4%甘油。结论本实验筛选出复方左旋肉碱涂膜剂制剂处方最优配比与用量,可供该制剂成型工艺及透皮试验研究参考。OBJECTIVE To provide a theoretical basis for industrialized production of compound L-carnitine coating agent by op- timizing the prescription. METHODS Using the time of coating formation as the evaluation index, Central composite design was used to optimize the ratio of film-former and plasticizer on the basis of single factor experiments. RESULTS The film-former is 15.4% a- crylic resin Ⅱ, and the plasticizer is 10.4% glycerin. CONCLUSION In this paper, the optimal formulation and dosage of compound L-carnitine coating agent was screened. This formulation can provide reference for the molding process of the preparation and the experiment of percutaneous absorption.

关 键 词：复方左旋肉碱涂膜剂 响应面设计试验法 成膜时间 丙烯酸树脂Ⅱ 

分 类 号：R944[医药卫生—药剂学]