血浆(1,3)-β-D-葡聚糖在老年慢性阻塞性肺疾病急性加重期并发侵袭性肺部真菌感染的诊断价值  

Value of Plasma(1,3)-β-D Glucan in Diagnosis of the Elderly Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated With Invasive Pulmonary Fungal Infection

作　　者：赵兰兰[1] 刘远程[1] 钱效森[1] 

机构地区：[1]民航总医院呼吸内科,北京100123

出　　处：《中国卫生标准管理》2017年第7期96-97,共2页China Health Standard Management

摘　　要：目的探讨血浆(1,3)-β-D-葡聚糖(G试验)检测在老年慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者并发侵袭性肺部真菌感染(IPFI)诊断中的临床应用价值。方法回顾性分析呼吸内科2014年5月—2016年1月临床疑似IPFI的老年AECOPD患者共149例,根据诊断标准确定是否发生IPFI,分析其血浆(1,3)-β-D葡聚糖含量和真菌培养结果。结果 G试验灵敏度66.67%,特异度74.04%;真菌培养灵敏度55.56%,特异度71.15%。结论血浆G试验定量测定具有快速、敏感的特点,对于老年AECOPD患者并发IPIF的临床诊断具有重要意义。Objective To explore the clinical value of plasma （1,3） -β-D glucan（G） test in diagnosis of the elderly patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） complicated with invasive pulmonary fnngal infection （IPFI）. Methods A retrospective study was performed for 149 elderly AECOPD patients from respiratory medicine, from May 2014 to January 2016, which suspected to suffer from IPFI. The serum samples were collected in all patients for G test and fungal culture, and the difference between the two test methods was analyzed. Results The sensitivity of G test was 66.67%, the specificity was 74.04%. The fungal culture was 55.56%, 71.15% respectively. Conclusion The quantitative detection of G test is a rapid and sensitive method, which is helpful for diagnosis the elderly AECOPD complicated with IPFI.

关 键 词：(1 3)-β-D-葡聚糖 老年人 慢性阻塞性肺疾病急性加重期 侵袭性肺部真菌感染 

分 类 号：R446[医药卫生—诊断学]