负极性驻极体与5-氟尿嘧啶对大鼠创面愈合的影响  

Effect of negative polypropylene electret and 5-fluoorouracil on skin wound healing of rats

作　　者：黄平[1] 徐立丽[1] 梁媛媛[1] 郭鑫[1] 梁合鹃 崔黎丽[2] 江键[1] 

机构地区：[1]第二军医大学基础部数理教研室,上海200433 [2]第二军医大学药学院无机化学教研室,上海200433

出　　处：《解剖学杂志》2017年第2期176-180,共5页Chinese Journal of Anatomy

基　　金：国家自然科学基金(51477175)

摘　　要：目的:比较不同表面电位的负极性驻极体与5-氟尿嘧啶(5-FU)对大鼠创面愈合的影响。方法:利用电晕充电技术与药剂学方法制备不同表面电位的负极性驻极体贴剂、5-FU贴剂、-2 000 V驻极体5-FU贴剂,借助等温表面电位测量、光学显微镜等手段,研究负极性驻极体贴剂与-2 000 V驻极体5-FU贴剂外静电场的稳定性以及上述三类贴剂对大鼠创面愈合的影响。结果:不同表面电位负极性驻极体贴剂与-2 000 V驻极体5-FU贴剂的等效表面电位随时间增加,均按指数规律衰减,能够给创面提供较为稳定的外静电场;不同表面电位负极性驻极体贴剂对创面愈合具有促进作用,而且等效表面电位越大,创面愈合越快;5-FU对创面愈合具有抑制作用,而将-2 000 V驻极体与5-FU联用可减轻5-FU对创面愈合的抑制作用。结论:负极性驻极体对创面愈合有促进作用,5-FU能延缓创面愈合,若合理利用两者,可以调控创面愈合和抑制增生性瘢痕生长。Objective： To compare the effect of negative polypropylene（PP） electrets with different surface potentials with that of the 5-fluoorouraeil（5-FU） on skin wound healing of rats. Methods： The corona charged electret patches with different surface potentials, 5-FU patch and --2 000 V PP electret 5-FU patch were prepared. By means of surface potential measurement, optical microscope, the stability of the electrostatic field of electret patch and electrets drug patch, as well as the effect of the above three kinds of patches to wound healing were studied. Results： All the electret and electret drug patches had stable electrostatic field to act on the wound surface. The wound healing effect of eleetret patch was proportional to the surface potential of the electret. 5-FU inhibited the wound healing. However, the electret drug patch could reduce the inhibitory action of the 5-FU to would healing. Conclusion： Negative PP electret can promote the wound healing, while 5-FU delays the wound healing. The combination of electret and 5 FU could be a better way to regulate the wound healing and inhibit the growth of hyperplastic scar.

关 键 词：驻极体 5-氟尿嘧啶 创面愈合 静电场 大鼠 

分 类 号：R641[医药卫生—外科学]