C反应蛋白及血清铁调素在肿瘤患者中的表达及其与贫血的关系  

The Expression of C-reactive Protein and Serum Hepcidin in Tumor Patients and Its Relationship with Anemia

作　　者：程旭[1] 潘湘涛[1] 张媛[1] 李蓉[1] 王金湖[1] 陆晔[1] 

机构地区：[1]苏州大学附属太仓医院(太仓市第一人民医院)血液肿瘤科,江苏太仓215400

出　　处：《中国继续医学教育》2017年第7期44-45,共2页China Continuing Medical Education

摘　　要：目的研究肿瘤患者C反应蛋白及血清铁调素的表达情况及其与贫血的关系。方法应用双抗夹心酶联免疫吸附试验(ABC-ELISA)方法检测120例肿瘤患者的血清C反应蛋白、铁调素,同时检测患者铁蛋白及血红蛋白水平。结果 C反应蛋白正常组的贫血发生率明显低于C反应蛋白升高组(P<0.01)。C反应蛋白正常组血红蛋白高于C反应蛋白升高组,而铁调素、铁蛋白水平低于C反应蛋白升高组(P<0.01)。C反应蛋白升高的患者中,贫血组铁调素、铁蛋白水平高于无贫血组(P<0.05)。结论肿瘤患者C反应蛋白升高可导致铁调素升高,进而导致的铁失利用是肿瘤性贫血发生的重要原因。Objective To study the expression of C-reactive protein （CRP） and serum hepcidin in tumor patients and its relationship with anemia. Methods ABC-ELISA was used to detect the expression of CRP and serum hepcidin in 120 cases of tumor patients, serum ferritin and hemoglobin （Hb） was detected at the same time. Results The anemia rate in normal CRP group was significantly lower than that in higher CRP group （P〈0.01）. The level of Hb in normal CRP group was higher than that in higher CRP group, but hepcidin and ferritin were lower than that in higher CRP group, there were significant difference between the two group （P〈0.01）. The hepcidin and ferritin level in anemia group of the higher CRP patients, which were higher than the group without anemia （P〈0.05）. Conclusion The elevation of CRP could lead to the increasing expression of hepcidin, and could result in iron-restriction which was an important reason of anemia of cancer.

关 键 词：C反应蛋白 铁调素 肿瘤 贫血 

分 类 号：R977[医药卫生—药品]