健康教育配合利拉鲁肽单药治疗新诊断超重2型糖尿病患者的临床分析  

Clinical analysis of health education with Liraglutide monotherapy treatment of newly diagnosed overweight patients with type 2 diabetes

作　　者：王海燕[1] 刘慧霞[1] 

机构地区：[1]中南大学湘雅医院老年内分泌科,湖南长沙410008

出　　处：《中国当代医药》2017年第11期51-54,共4页China Modern Medicine

摘　　要：目的分析健康教育配合利拉鲁肽单药治疗新诊断超重2型糖尿病的治疗效果,为临床应用提供理论依据及参考。方法选取2014年6月~2016年5月我院收治的30例超重2型糖尿病患者为研究对象,采用随机数字表法分为健康教育联合组(n=15)和利拉鲁肽组(n=15)。对健康教育联合组患者进行健康教育的同时配合利拉鲁肽单药治疗,利拉鲁肽组仅给予利拉鲁肽单药治疗,皮下注射利拉鲁肽18 mg/d,连续注射12周,对比两组的血压、体重、体重指数(BMI)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)、空腹C肽(FC-P)、HOMA-IR(CP)、Homa islet(CP)、糖化血红蛋白(Hb A1c)、餐后2 h血糖(2 h PG)、空腹血糖(FPG)等指标。结果治疗12周后,两组患者的FPG、2 h PG、Hb A1c、体重、BMI、SB、FC-P、HOMA islet、HOMA-IR、TC、TG和LDL-C较治疗前均有明显的降低,且健康教育联合组降低更加显著,两组治疗前后差值比较,差异有统计学意义(P<0.05)。结论健康教育配合利拉鲁肽可有效作用于超重2型糖尿病患者,且效果优于单独利拉鲁肽治疗,能有效控制超重2型糖尿病患者的体重,降低血压,控制FPG及2 h PG,并能起到调脂的作用。Objective To explore the treatment methods of health education with Liraglutide monotherapy treatment of newly diagnosed overweight patients with type 2 diabetes,which can further provide the theoretical basis and reference for clinical application.Methods 30 cases of overweight patients with type 2 diabetes from June 2014 to May 2016 in our hospital were selected as the research object,they were divided into education united group （n=15） and Liraglutide group （n=15） using the random number table method.Liraglutide group was given a separate Liraglutide monotherapy, subcutaneous injection,18 mg/d,injection 12 weeks in a row,education united group was given Liraglutide monotherapy and health education.Then the difference of blood pressure,body weight,body mass index （BMI）,low density lipoprotein cholesterol （LDL-C）,triglyceride （TG）,total cholesterol （TC）,fasting C peptide （FC-P）,HOMA-IR（CP）,HOMA IR islet （CP）, glycosylated hemoglobin （HbA 1 c）,postprandial 2 h blood glucose （2 h PG）,fasting plasma glucose （FPG）,and other indicators was compared between the two groups.Results The FPG,2 h PG,HbAlc,weight,BMI,SB,FC-P,HOMA islet,HOMA-IR, TC,TG and LDL-C were significantly lower compard with before treatment,and education united group had more signifi- cantly reduce compared with Liraglutide group,the difference value of before and after treatment in the two groups had statistically significant difference （P〈O.O5）.Conclusion The combination with health education and LiraglUtide is a kind of effective treatment to overweight type 2 diabetes patients,and superior than the Liraglutide monotherapy,because it can effectively control overweight type 2 diabetes patients with body weight,lower blood pressure, FPG,2 h PG,and it plays a role in lipid regulation as well.

关 键 词：健康教育 利拉鲁肽 超重2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]