桂枝茯苓丸联合妇乐片对子宫内膜异位症的临床疗效  

Effects of Guizhi Fuling Pills Combined with Fu Le Tablets on the Levels of Serum AFP and LSA in the Patients with Endometriosis and Its Clinical Efficacy

作　　者：杨蕾[1] 黄志兰[1] 敬源 侯大乔[1] 谢婷婷[2] YANG Lei HUANG Zhi-lan JING Yuan HOU Da-qiao XIE Ting-ting(I Department of Gynecology, Shaanxi Baoji People＇s Hospital, Baoji, Shaanxi, 721000, China Department of Obstetrics, the First Affiliated Hospital of The Fourth Military Medical University, Xijing Hospital, Xi＇an, Shaanxi, 710032, China)

机构地区：[1]宝鸡市人民医院妇科,陕西宝鸡721000 [2]第四军医大学第一附属医院西京医院产科,陕西西安710032

出　　处：《现代生物医学进展》2017年第12期2353-2356,共4页Progress in Modern Biomedicine

基　　金：陕西省科技攻关项目(2012K18-12)

摘　　要：目的:探讨桂枝茯苓丸联合妇乐片对子宫内膜异位症患者血清甲胎蛋白(AFP)、血清脂质结合唾液酸(LSA)及临床疗效的影响。方法:选取我院确诊并治疗的子宫内膜异位症患者68例,按随机数字表法进行分组,每组34例。对照组患者予以妇乐片口服治疗;研究组患者在对照组用药基础上予以桂枝茯苓丸联合治疗,所有患者连续服药6个月。观察两组患者治疗前后血清甲胎蛋白(AFP)、血清LSA、肿瘤坏死因子-α(TNF-α)及血管内皮生长因子(VEGF)水平的变化情况、临床疗效及不良反应发生率。结果:研究组治疗后临床有效率91.18%,高于对照组治疗后临床有效率70.59%,差异具有统计学意义(P<0.05);与对照组比较,研究组治疗后血清AFP、LSA、TNF-α、VEGF水平降低,差异具有统计学意义(P<0.05);对照组不良反应发生率为8.24%,研究组不良反应发生率为5.88%,两组间不良反应发生率无统计学意义(P>0.05)。结论:采用桂枝茯苓丸联合妇乐片治疗子宫内膜异位症,能有效提高患者的临床疗效,推测其机制与降低血清AFP、LSA、TNF-α、VEGF水平有关。Objective： To investigate the effects of guizhi ruling pills combined with fu le tablets on the levels of serum AFP and LSA and its clinical efficacy for patients with endometriosis. Methods： 68 patients with endometriosis who were treated in our hospital were selected and randomly divided into experiment group and control group, with 34 cases in each group. The patients in the control group were treated with fu le tablets; the patients in the experiment group were treated on the base of the control group with guizhi fuling pills. The serum AFP （AFP）, serum LSA, tumor necrosis factoroα（TNF-α）, vascular endothelial growth factor （VEGF） levels of the two groups were observed, and the clinical efficacy and adverse reactions was detected and compared. Results： After treatment, the clinical effective rate of the experiment group was 91.18 %, significantly higher than 70.59 % of the control group with statistical significance （P 〈 0.05）; compared with the control group, the serum AFP, LSA, TNF-α and VEGF levels of the experiment group were decreased after treatment, and the differences were statistically significant （P 〈 0.05）. The patients in two groups had no malignant adverse reactions, and incidence of the adverse reactions between two groups had no difference （P 〉 0.05）. Conclusions： Guizhi fuling pills combine with fu le tablets can effectively improve the patient＇s clinical efficacy in the treatment of endometriosis, its mechanism might be related to reduction of the serum AFP, LSA, TNF -α and VEGF levels.

关 键 词：桂枝茯苓丸 妇乐片 子宫内膜异位症 AFP LSA 

分 类 号：R711.71[医药卫生—妇产科学]