表观遗传学及其研究方法  

Epigenetics and Its Research Methods

作　　者：朱锋[1] 王旭[1] 刘倩莹 陆启荣[1] 黄德玉[1] 刘振利[1] 戴梦红[1] 袁宗辉[1] ZHU Feng WANG Xu LIU Qian-ying LU Qi-rong HUANG De-yu LIU Zhen-li DAI Meng-hong YUAN Zong-hui(National Reference Laboratory of Veterinary Drug Residues （HZAU） and MA O Key Laboratory for Detection of Veterinary Drug Residues, MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, 430070, Chin)

机构地区：[1]华中农业大学,国家兽药残留基准实验室(HZAU)/农业部食品安全评价重点开放实验室,湖北武汉430070

出　　处：《现代生物医学进展》2017年第12期2371-2376,共6页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(31272614)

摘　　要：表观遗传学是一门重要的生命学科,主要包括DNA的甲基化、组蛋白修饰以及非编码RNA等内容,其中任何一方面的表观遗传学变化对生物体的生命过程都有重要的影响。近年来随着生命科学的快速发展,表观遗传学越来越受到人们的关注,各种先进科技的应用也使得表观遗传学实验技术得到快速的发展。本文对DNA甲基化、组蛋白修饰及非编码RNA的基本内容及实验方法进行了综述,并对不同的研究方法进行分析,有利于表观遗传学的深入研究。Epigenetics is an important discipline of life, mainly including DNA methylation, histone modification, non-coding RNA and some other changes. Any changes of epigeneties will have an important impact on the development of body. With the rapid development of life science, epigenetics has got more and more attention and epigenetics has a rapid development with the various applications of advanced technologies in recent years. Methods of experiment and the basic content of DNA methylation, histone modification and non-coding RNA are summarized, and different ways of study on epigenetics are analyzed in this paper. And it is good for the deep research of epigenetics.

关 键 词：表观遗传学 DNA甲基化 组蛋白修饰 非编码RNA 

分 类 号：Q34[生物学—遗传学]