外排转运蛋白介导的抗真菌药物耐药研究进展  

Efflux Transporter-Mediated Antifungal Drug Resistance

作　　者：王威[1] 邵龙[1] 郑娜[1] 蒋胶胶 张家堂[1] WANG Wei SHA ZHENG Na JIANG Jiao-jiao ZHANG Jia-tang(Department of Neurology, General Hospital of the People＇s Liberation Army, Beijing, 100853, China)

机构地区：[1]中国人民解放军总医院神经内科,北京100853

出　　处：《现代生物医学进展》2017年第12期2377-2380,共4页Progress in Modern Biomedicine

基　　金：全军医学科技"十二五"科研项目(CWS11J064)

摘　　要：近年来,随着广谱抗生素,免疫抑制剂,抗肿瘤化疗药物的广泛应用,器官移植的普遍开展以及AIDS患者的逐年增加,各系统侵袭性真菌感染日益增多。抗真菌药物的大量应用使得真菌耐药现象日渐严重。大量研究表明,耐药真菌细胞膜上外排转运蛋白的过量表达对抗真菌药物耐药形成起到重要作用。ATP结合盒式蛋白(ABC转运体)和易化扩散载体超家族蛋白(MFS转运体)便是其中最重要的两种。本文从ABC及MFS转运体的结构和功能出发,分析其在抗真菌药物耐药形成中的作用,并对相关研究进展进行综述。The incidence of life-threatening fungal infections has increased gradually in recent years due to the widespread use of broad-spectrum antimicrobial agents, immunosuppressants, anti-tumor drugs, the extensive development of organ transplantation, and the increasing number of patients with AIDS. Resistance to antifimgal agents is becoming an increasingly significant clinical problem. Over-expression ofeffiux transporters at the plasma membrane may be responsible for the high-level drug resistance. There are two main superfamilies of effiux transporters, the ATP-binding cassette （ABC transporters） and the major facilitator superfamily （MFS transporters）. This review focuses on the structure and function of ABC and MFS transporters of different fungal species to emphasize the recent advancement in this field.

关 键 词：ATP结合盒式蛋白 易化扩散载体超家族蛋白 抗真菌药物 耐药机制 

分 类 号：R978.5[医药卫生—药品] R379[医药卫生—药学]