GSTM1、GSTT1基因多态性与抗结核药物所致肝损害的相关性分析  

Association of genetic polymorphisms of GSTM1 and GSTT1 with anti-tuberculosis drugs induced liver injury

作　　者：祖丽娅.沙塔尔 顾佳怡[2] 马晨晨[1] 秦丽岩[1] 毛英[1] 张英[1] 向阳[1] Zuliya Shataer GU Jiayi MA Chenchen QING Liyan MAO Ying ZHANG Ying XIANG Yang(Department of Epidemiology and Health Statistics, College of Public Health, Xinjiang Medical University, Urumqi 830011, China College of Public Health, Southeast University, Nanjing 210000, China)

机构地区：[1]新疆医科大学公共卫生学院流行病学与卫生统计学教研室,乌鲁木齐830011 [2]东南大学公共卫生学院,江苏南京210000

出　　处：《新疆医科大学学报》2017年第6期762-766,共5页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30960328)

摘　　要：目的探讨GSTM1、GSTT1基因多态性与抗结核药物所致肝损害(ATLI)的关系。方法采用多重等位基因特异聚合酶链反应(PCR)检测2 791例肺结核患者的GSTM1和GSTT1基因多态性,治疗至2个月末肝功能正常的患者有2 303例,发生ATLI的患者有108例,分析其GSTM1、GSTT1基因多态性与ATLI的关系。结果 GSTM1基因多态性在所有相关因素间的分布差异均无统计学意义(P均>0.05),GSTT1基因多态性在年龄、民族、服用保肝药及甲肝因素间的分布差异有统计学意义(P≤0.05)。GSTM1基因型是ATLI发生的影响因素(P<0.05)。单纯具有GSTM1缺失基因型和同时具有GSTM1、GSTT1缺失基因型是ATLI发生的影响因素,OR(95%CI)为1.822(1.114~2.902)、1.761(1.003~3.093)。结论 GSTM1基因多态性与抗结核药物所致的肝损害发生有关。Objective To explore the association between ATLI and genetic polymorphisms of GSTM1, GSTT1. Methods 2 791 patients with pulmonary tuberculosis were enrolled, genetic polymorphisms of GSTM1 and GSTT1 was detected using multiple allele specific polymerase chain reaction （PCR） of the 2 791 cases of patients, 2 303 cases of patients whose liver function recovery were normal at the end of the administration,for 2 months,the patient with ATLI were 108. Analyzed was the relationship between the Genetic polymorphisms of GSTM1 and GSTT1 versus ATLI. Results There was no significant difference of GSTM1 gene polymorphism in the distribution of all the relevant factors. The distribution of GSTT1 gene polymorphisms was shown to be statistically significant differences in age, ethnic, taking hepatopro- tective drugs, hepatitis A group （P 〈0.05） . GSTM1 genotype was shown to be the influencing factor of the development of ATLI （P 〈0.05）. The genotype with GSTM1 deletion and GSTM1 together with GSTT1 deletion were analyzed to be the influencing factors of ATLI , OR （95% CI） was 1.822 （1.114 to 2. 902）, 1.761 （1.003 to 3.093） respectively. Conclusion ciated with the development of liver injury induced by anti-tuberculosis drug.

关 键 词：肺结核 抗结核药物所致肝损害 GSTM1 GSTT1 

分 类 号：R978.3[医药卫生—药品]