血小板衍生微颗粒在血管内皮损害中的作用机制  

Damage mechanism on vascular endothelium by platelet-derived microparticle

作　　者：金京[1] 俞海国[1] 

机构地区：[1]南京医科大学附属南京儿童医院,210000

出　　处：《国际儿科学杂志》2017年第4期273-275,280,共4页International Journal of Pediatrics

摘　　要：血小板衍生微颗粒（platelet—derived microparticle，PMP）是血小板在各种刺激作用下活化而释放的一种超微膜性囊泡，直径小于1．0μm。这些血小板微粒由浆膜囊性碎片和α-颗粒组成。血液中PMP的形成、释放及水平可反映血小板活化。PMP可以促凝血，促进血小板和白细胞黏附于内皮下膜，促进血管生成和刺激血管平滑肌的增殖。在动脉粥样硬化、糖尿病、川崎病等多种血管性疾病患者血液中PMP水平升高，该文就血管内皮损伤过程中PMP的可能作用机制作一综述。Platelet-derived microparticle （PMP） is a heterogeneous vesicle （ 〈 1 pan） generated from the plasma membrane when platelets are activated by various stimulation, which is composed of serous cystic fragments and a-granules. The formation, release and level of circulating PMP can reflect the platelet activation. The functions of PMP include facilitating coagulation, promoting adhesion of platelet and leukocyte to the subendo- thelial membrane, promoting angiogenesis and stimulating the proliferation of vascular smooth muscle. High level of PMP appears in many cardiovascular diseases such as atherosclerosis, diabetes mellitus, Kawasaki disease and so on. This paper is to review the mechanism of PMP in the vascular endothelial injury.

关 键 词：血小板衍生微颗粒 血管内皮 动脉粥样硬化 糖尿病 川崎病 

分 类 号：R54[医药卫生—心血管疾病]