肺表面活性蛋白D和人类I型蛋白在肺炎支原体肺炎患儿支气管肺泡灌洗液和血清中的水平研究  

Level of pulmonary surfactant protein D and human type I protein in bronchoalveolar lavage fluid and serum in children with mycoplasma pneumoniae pneumonia

作　　者：桂莹[1] 李晓岚[2] 

机构地区：[1]湖北大学医院儿科,武汉430062 [2]武汉市汉口医院儿科,430012

出　　处：《国际儿科学杂志》2017年第4期291-293,共3页International Journal of Pediatrics

摘　　要：目的评估肺炎支原体肺炎患儿支气管肺泡灌洗液和血清中的肺表面活性蛋白D（SP—D）和人类I型蛋白（HTI-56）的水平，探讨其作为肺炎支原体肺炎潜在的生物标志物的意义。方法该研究采用回顾性研究的方法，收集2011年6月至2016年6月我院儿科收治的肺炎支原体肺炎患儿57例。本研究测定了患儿的支气管肺泡灌洗液和血清中的SP-D和HTI-56的水平，并且在单侧肺部感染和双侧肺部感染的患儿之间进行比较。结果与未感染肺部的支气管肺泡灌洗液样本相比较，在感染肺部的支气管肺泡灌洗液样品中的SP—D和HTI-56水平明显升高（P〈0．05）；然而在单侧肺部感染和双侧肺部感染的患儿的SP-D和HTI-56的血清水平差异无统计学意义（P〉0．05）。结论在感染肺部的支气管肺泡灌洗液样品中的高水平的SP-D和HTI-56可反映由肺炎支原体引起的肺泡上皮细胞的损伤。Objective To evaluate the levels of pulmonary surfactant protein D（SP-D） and 56-kD human type I protein（HTI-56） in bronchoalveolar lavage fluid and serum of children with mycoplasma pneumoniae pneumonia, as well as their potential as biomarkers of mycoplasma pneumoniae pneumonia. Methods A retrospective study was conducted in 57 children with mycoplasma pneumoniae pneumonia from June 2011 to June 2016 in our hospital. In this study ,the levels of SP-D and HTI-56 in bronchoalveolar lavage fluid and serum were determined and compared between unilateral lung infection and bilateral lung infection. Results SP-D and HTI- 56 levels were significantly higher in bronchoalveolar lavage fluid samples （P 〈 0. 05 ）compared with bronchoal- veolar lavage fluid samples from uninfected lungs （ P 〈 0. 05 ）. However, the serum levels of SP-D and HTI-56 in children with unilateral lung infection and bilateral pulmonary infection were not significantly different （ P 〉 0.05）. Conclusion High levels of SP-D and HTI-56 in bronchoalveolar lavage fluid samples from infected lungs may reflect damage to alveolar epithelial cells caused by mycoplasma pneumoniae.

关 键 词：肺炎支原体肺炎 支气管肺泡灌洗液 肺表面活性蛋白D 人类I型蛋白 

分 类 号：R725.6[医药卫生—儿科]