心得宁口服液对大鼠慢性心衰模型的影响  

Effect of Propranolol Oral Liquid on Chronic Heart Failure Model of Rats

作　　者：赵京生[1] 郭长升[1] 易伟国[1] 张玲昂[1] 张正臣[1] 

机构地区：[1]解放军第152中心医院,河南平顶山467000

出　　处：《中国现代应用药学》2017年第3期337-340,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：河南省科技发展计划项目(132102310408)

摘　　要：目的探讨心得宁口服液对大鼠慢性心衰模型血清中血管紧张素Ⅱ(Ang-Ⅱ)、B型脑钠肽(BNP)、心肌肌钙蛋白Ⅰ(cTnⅠ)、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-a(8)、磷酸腺苷(ATP)和白介素-6(IL-6)水平的影响。方法采用每周腹腔注射盐酸多柔比星(2 mL·kg^(-1)腹腔注射,每周1次,共6周,累积总量24 mg·kg-1)建立大鼠慢性心衰模型,观察20,10,5 m L·kg^(-1)心得宁口服液对慢性心衰模型大鼠血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-a、ATP和IL-6水平的影响。结果大鼠慢性心衰模型造模成功。与模型组相比,20,10,5 m L·kg^(-1)心得宁口服液能显著降低血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-α水平(P<0.01);显著升高ATP水平(P<0.01),20,10 mL·kg^(-1)心得宁口服液能显著降低血清IL-6水平(P<0.01),5 m L·kg^(-1)心得宁口服液能明显降低血清IL-6水平(P<0.05)。结论心得宁口服液可明显改善大鼠慢性心衰模型的作用。OBJECTIVE To investigate the effect of propranolol oral liquid on serum levels of angiotensin Ⅱ（Ang-Ⅱ）, B-type brain natriuretic peptide（BNP）, cardiac troponin Ⅰ（c TnⅠ）, C-reactive protein（CRP）, tumor necrosis factor alpha（TNF-α）, adenosine monophosphate（ATP） and interleukin 6（IL-6） on rats with chronic heart failure. METHODS The rat model of chronic heart failure were established by weekly intraperitoneal injection of doxorubicin hydrochloride. And the levels of Ang-Ⅱ, BNP, c TnⅠ, CRP, TNF-α, ATP and IL-6 influenced by propranolol oral liquid were observed in chronic heart failure rats. RESULTS The rat model of chronic heart failure rats was successed. Compared with the model group, the high, middle and low dose of practolol oral liquid can significantly reduce the serum Ang-Ⅱ, BNP and c TnⅠ, CRP, TNF-α level（P〈0.01）; high, middle and low doses of practolol oral liquid can significantly increase the ATP level（P〈0.01）. High, middle dose practolol oral liquid can significantly decrease the serum IL-6 levels（P〈0.01）, low dose of practolol oral liquid group can significantly decrease the serum IL-6 levels（P〈0.05）. CONCLUSION The effect of the chronic heart failure model of rats can be improved obviously by the oral administration of propranolol.

关 键 词：心得宁口服液 大鼠 慢性心衰模型 芪苈强心胶囊 

分 类 号：R965.2[医药卫生—药理学]