血清25-羟维生素D水平与初诊原发性高血压患者动态动脉硬化指数的相关性研究  

Correlation between Serum 25-hydroxyvitamin D Level and Ambulatory Arterial Stiffness Index in Newly Diagnosed Patients with Essential Hypertension

作　　者：王伟[1] 田祥[1] 张同乐[1] 

机构地区：[1]河北省保定市第一中心医院心内科,071000

出　　处：《实用心脑肺血管病杂志》2017年第3期11-14,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨血清25-羟维生素D水平与初诊原发性高血压患者动态动脉硬化指数(AASI)的相关性。方法选取2015年1月—2016年5月在保定市第一中心医院就诊的初诊原发性高血压患者158例,根据血清25-羟维生素D水平分为维生素D缺乏组98例和非维生素D缺乏组60例。采用24 h动态血压监测仪监测两组患者动态血压,并计算AASI。比较两组患者一般资料、实验室检查指标及AASI。血清25-羟维生素D水平与初诊原发性高血压患者AASI的相关性分析采用Pearson相关性分析;AASI的相关因素分析采用单因素线性回归分析及多因素线性回归分析。结果两组患者性别、年龄、收缩压、舒张压、平均动脉压、血小板计数及血红蛋白、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平比较,差异无统计学意义(P>0.05);维生素D缺乏组患者AASI高于非维生素D缺乏组(P<0.05)。Pearson相关性分析结果显示,血清25-羟维生素D水平与初诊原发性高血压患者AASI呈负相关(r=-0.343,P<0.01)。多因素线性回归分析结果显示,血清25-羟维生素D水平与初诊原发性高血压患者AASI独立相关(β=-0.355,P<0.05)。结论血清25-羟维生素D水平与初诊原发性高血压患者AASI呈负相关,血清25-羟维生素D降低时AASI升高,且二者独立相关。Objective To explore the correlation between serum 25 - hydroxyvitamin D level and ambulatory arterial stiffness index （AASI） in newly diagnosed patients with essential hypertension. Methods A total of 158 newly diagnosed patients with essential hypertension were selected in the First Central Hospital of Baoding from January 2015 to May 2016, and they were divided into A group （with vitamin D deficiency, n = 98） and B group （without vitamin D deficiency, n = 60） according to serum 25 - hydroxyvitamin D level, meanwhile 24 - hour ambulatory blood pressure monitor was used to monitor the pressure, and AASI was calculated. General information, laboratory examination results and AASI were compared between the two groups. Correlation between serum 25 - hydroxyvitamin D level and AASI of newly diagnosed patients with essential hypertension was analyzed by Pearson correlation analysis, and related factors of AASI was analyzed by univariate linear regression analysis and multivariate linear regressions analysis. Results No statistically significant differences of gender, age, SBP, DBP, MAP, PLT, Hb, TC, TG, HDL-C or LDL-C was found between the two groups （P 〉0. 05）, while AASI of A group was statistically significantly higher than that of B group （ P 〈 0. 05 ）. Pearson correlation analysis results showed that,serum 25 - hydroxyvitamin D level was negatively correlated with AASI of newly diagnosed patients with essential hypertension （ r = - 0. 343, P 〈 0.01 ）. Multivariate linear regressions analysis results showed that, serum 25 - hydroxyvitamin D level was independently correlated with AASI of newly diagnosed patients with essential hypertension （β = - 0. 355, P 〈 0. 05 ）. Conclusion Serum 25 - hydroxyvitamin D level is negatively correlated with AASI in newly diagnosed patients with essential hypertension, when the serum 25- hydroxyvitamin D level decreased, the AASI significantly elevated, meanwhile serum 25 - hydroxyvitamin D level is independently correlated with AASI.

关 键 词：高血压 25-羟维生素D 血管硬化 动态动脉硬化指数 

分 类 号：R544.1[医药卫生—心血管疾病]