尿微量白蛋白/肌酐比值与2型糖尿病患者颈动脉内膜中膜厚度及颈动脉僵硬度的关系研究  

Relationship between Urinary Microalbumin/Creatinine Ratio and Carotid Intima-media Thickness and Carotid Artery Stiffness of Patients with Type 2 Diabetes Mellitus

作　　者：曹文钦 唐菲[2] 

机构地区：[1]湖北省大冶市中医医院,435100 [2]湖北省黄石市中心医院,435000

出　　处：《实用心脑肺血管病杂志》2017年第3期38-41,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的分析尿微量白蛋白/肌酐比值(UACR)与2型糖尿病患者颈动脉内膜中膜厚度(CIMT)及颈动脉僵硬度的关系。方法选取湖北省大冶市中医医院2012年1月—2015年1月收治的2型糖尿病患者100例,根据UACR分为正常组(UACR<30 mg/g)41例和升高组(30 mg/g≤UACR≤300 mg/g)59例。比较两组患者一般资料、血压、血脂指标、血糖指标、CIMT及脉搏波传导速度(PWV),UACR的相关因素分析采用Pearson相关性分析和多元逐步回归分析。结果两组患者性别、舒张压(DBP)及总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);升高组患者年龄和CIMT大于正常组,收缩压(SBP)、脉压(PP)、空腹血糖(FPG)及糖化血红蛋白(Hb A1c)高于正常组,高密度脂蛋白胆固醇(HDL-C)水平低于正常组,PWV快于正常组(P<0.05)。Pearson相关性分析结果显示,UACR与2型糖尿病患者年龄(r=3.29)、SBP(r=2.81)、PP(r=1.48)、LDL-C(r=2.66)、FPG(r=4.29)、HbA_(1c)(r=3.32)、CIMT(r=2.98)、PWV(r=3.56)呈正相关(P<0.05);多元逐步回归分析结果显示,PP(β=1.18)、HbA_(1c)(β=1.01)、CIMT(β=2.47)、PWV(β=2.82)与2型糖尿病患者UACR独立相关(P<0.05);校正PP后,Hb A1c(β=1.26)、CIMT(β=2.51)、PWV(β=2.17)仍与2型糖尿病患者UACR独立相关(P<0.05)。结论 UACR与2型糖尿病患者CIMT及颈动脉僵硬度独立相关。Objective To analyze the relationship between urinary microalbumin/creatinine ratio （UACR） and carotid intima - media thickness （CIMT） and carotid artery stiffness of patients with type 2 diabetes mellitus. Methods A total of 100 patients with type 2 diabetes mellitus were selected in the Traditional Chinese Medicine Hospital of Daye from January 2012 to January 2015, and they were divided into A group （ with UACR 〈 30 mg/g, n =41 ） and B group （with UACR equal or over 30 mg/g but equal or less than 300 mg/g, n = 59）. General information, blood pressure, blood lipids index, blood glucose related index, CIMT and PWV were compared between the two groups, and related factors of UACR were analyzed by Pearson correlation analysis and multiple stepwise regression analysis. Results No statistically significant differences of gender, DBP, TC, TG or LDL-C was found between the two groups （ P 〉0. 05） ; age of B group was statistically significantly older than that of A group, CIMT of B group was statistically significantly thicker than that of A group, SBP, PP, FPG and HbA1, of B group were statistically significantly higher than those of A group, HDL-C of B group was statistically significantly lower than that of A grnup, while PWV of B group was statistically significantly faster than that of A group （ P 〈 0. 05 ）. Pearson correlation analysis resultsshowed that, UACR was positively correlated with age （r=3.29）, SBP （r=2.81）, PP （r=1.48）, LDL-C （r=2.66）, FPG （r=4.29）, HbAtc （r=3.32）, CIMT （r =2.98） and PWV （r=3.56） of patients with type 2 diabetes mellitus, respectively （P 〈 0. 05 ） ; multiple stepwise regression analysis results showed that, PP （β = 1. 18 ）, HbAtc （β= 1.01 ）, CIMT （β =2.47） and PWV （β = 2.82） was independently correlated with UACR of patients with type 2 diabetes mellitus, respectively （P〈0.05） ; after correction of PP, tlbAtc （β= 1.26）, CIMT （β =2.51 ） and PWV （β =2. 17） was still independently

关 键 词：糖尿病 2型 白蛋白尿 尿微量白蛋白/肌酐比值 颈动脉内膜中膜厚度 僵硬度 

分 类 号：R587.1[医药卫生—内分泌]