宫外发育迟缓早产儿部分生化代谢指标分析  

Analysis of Some Biochemical and Metabolic Indices of Premature Infants with Extrauterine Growth Retardation

作　　者：林晴晴[1] 王鉴 

机构地区：[1]贵州医科大学,贵州贵阳550004 [2]贵州医科大学附院新生儿科,贵州贵阳550004

出　　处：《贵州医科大学学报》2017年第4期459-463,共5页Journal of Guizhou Medical University

基　　金：贵州省科技厅科学技术基金[黔科合J字(2009)2160号]

摘　　要：目的:探讨宫外发育迟缓(EUGR)早产儿生化代谢指标的变化。方法:60例早产儿分为EUGR组及非EUGR组,于出生后7、14 d、3月龄、6月龄4个时间点测量两组早产儿的体格指标(体质量、身长、头围),并于同一时间点清晨取空腹外周静脉血检测清蛋白(ALB)、前清蛋白(PA)、胆固醇(TC)、三酰脂甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、INS、C肽、IGF-1,计算胰岛素抵抗指数(IRI)。结果:EUGR组7、14 d体质量低于非EUGR组,3月龄、6月龄体质量、头围、身长低于非EUGR组,体质量、头围及身长落后比例高于非EUGR组,差异有统计学意义(P<0.05);EUGR组7、14 d、3月龄、6月龄PA水平低于非EUGR组早产儿,3月龄、6月龄IGF-1水平低于非EUGR组,差异有统计学意义(P<0.05),两组新生儿PA、IGF-1水平随日龄增加有升高趋势;3月龄log INS高于非EUGR组,发生胰岛素抵抗(IR)的例数多于非EUGR组,差异有统计学意义(P<0.05)。结论:早产儿EUGR与PA水平、IGF-1水平和IR密切相关。Objective： To investigate the changes of biochemical and metabolic indices in premature infants with extrauterine growth retardation （EUGR）. Methods： Sixty premature infants are categorized into EUGR group and non-EUGR group. Physical indices （body weight, body length and head circumference） were detected in 7 d, 14 d, 3 and 6 months after birth, and at the same time fasting peripheral venous blood was drawn to examine the levels of albumin （ ALB）, prealbumin （ PA）, cholesterol （TC）, triglyceride （TG）, high density lipoprotein-cholesterol （HDL-C）, low density lipopro- tein-cholesterol （LDL-C）, fasting blood glucose （FBG）, insulin, C-peptide （CP）, insulin-like growth factor （IGF-I） , and insulin resistance index （IRI） was calculated. Results： The body weight of EUGR group infants was lower than non-EUGR group at 7 d and 14 d after birth （P 〈 0.05 ） ; body weight, head circumference and body length of EUGR group infants were lower than non-EUGR group at 3 and 6 months after birth （ P 〈 0.05 ）. The growth retardation rates of weight, head circumference and body length of EUGR group infants were higher than that of non-EUGR group at 3 and 6 months after birth （P 〈 0.05 ）. The level of PA of EUGR group was lower than that of non-EUGR group at 7 d, 14 d, 3 and 6 months after birth ; the level of IGF-1 of EUGR group was lower than that of non-EUGR group at $ and 6 months after birth （ P 〈 0.05 ） , the levels of PA and IGF-1 of all the groups tended to increase along with age increasing. The level of INS of EUGR group was higher than that of non-EUGR group at 3 months after birth （P 〈0.05） ; Occurrence of insulin resistance （IR） in EUGR group was higher than non-EUGR group in 3 months after birth （ P 〈 0.05 ）. Conclusions： The levels of PA, IGF-1 and IR are closely related to the EUGR of premature infant.

关 键 词：婴儿 早产 疾病 发育障碍 生化指标 代谢 

分 类 号：R725.89[医药卫生—儿科]