聚天冬氨酸/支化聚乙烯亚胺-甲基橙层层组装膜制备及负载缓释性能研究  

Preparation,load and sustained release properties of polyaspartic acid/branched polyethyleneimine-methyl orange layer by layer assembled film

作　　者：贾智信 师海岗 胡灯 李琼[1] 陈小玲[1] 赵彦生[1] 

机构地区：[1]太原理工大学化学化工学院,太原030024

出　　处：《化工新型材料》2017年第4期85-87,共3页New Chemical Materials

基　　金：国家自然基金青年基金项目(21304066);山西省科技攻关项目(20100311117)

摘　　要：以层层组装方法将聚天冬氨酸(PASP)、支化聚乙烯亚胺(PEI)、甲基橙(MO)在不同pH值下制得PASP/PEI-MO膜。探讨了PASP/PEI-MO膜中MO的负载性能以及在生理盐水中的释放性能。结果表明,当PEI-MO溶液pH值为8.3,PASP溶液pH值为3.8时,PASP/PEI-MO膜的负载量达到了最大,还具有较好的缓释效果,层层组装膜(PASP/PEI-MO)-20中MO在释放1500min时,MO的释放量达到0.095mg/cm^2;浸泡负载MO的释放量达到0.296mg/cm^2。PASP/PEI-MO based on polyaspartaic acid,branched polyethyleneimine and methyl orange（MO）as initial meterials was prepared through traditional immersion layer by layer assembly technique.The loading property of MO in PASP/PEI-MO and the release property in physiological saline solution were investigated.The results showed that the loading of PASP/PEI-MO reached the maximum when pH value of PEI-MO solution was 8.3and pH value of PASP solution was 3.8.And it had better sustained-release affect.The release amount of methyl orange in（PASP/PEI-MO）-20 reached 0.295mg/cm2 in the 1500 minutes.The release amount of methyl orange by soaking loading reached 0.296mg/cm2.

关 键 词：层层组装 聚合物复合物 支化聚乙烯亚胺 聚天冬氨酸 药物缓释 

分 类 号：TQ317[化学工程—高聚物工业] TQ460.1