超临界CO2诱导相分离法工艺条件对左旋聚乳酸多孔支架孔形貌和结构的优化调控  

Optimization of pore morphology and structure of polylactic acid scaffold by adjustment of preparation conditions by supercritical carbon dioxide induced phase separation method

作　　者：王芬[1,2] 唐婧[1] 周绿山[1] 刘长路[1] 罗晓刚[2] 

机构地区：[1]四川文理学院化学化工学院,达州635000 [2]武汉工程大学化工与制药学院,绿色化工过程教育部重点实验室,新型反应器和绿色化学技术湖北重点实验室,武汉430073

出　　处：《化工新型材料》2017年第4期91-93,97,共4页New Chemical Materials

基　　金：四川省教育厅资助科研项目(15ZB0322)

摘　　要：采用超临界CO_2诱导相分离法制备了左旋聚乳酸多孔支架材料,研究了原料的分子量、超临界CO_2的压力和温度对制备多孔材料的孔结构如孔隙率、大孔孔径及内连通孔径的影响和优化调控。与传统方法所制得的材料相比较,制备的多孔材料杂质少,分布均匀,孔洞表面粗糙,而且在大孔之间布满了直径为5~20μm的微孔。同时通过SEM、FT-IR以及DSC对优化条件制备的产品表面及截面结构、形貌及理化性质进行了系统分析研究。结果表明,制备的支架材料的孔结构和形貌可以通过对左旋聚乳酸原料的分子量、处理样品的压力和温度等工艺参数优化选择来对产品结构进行优化调控而适合不同生物及医学应用需要。The porous PLLA scaffolds were prepared successfully by the supercritical CO_2 induced phase separation mothed.The influences of the molecular weight of PLLA,the pressure and temperature on the pore structure,such as the porosity,pore size and inner connected pore size,were investigated.Compared with the traditional method,the prepared porous material had less impurities,uniform distribution,rough surface,and had a lots of the pores with 5~20μm diameter in these large pores.The physicochemical properties and morphology of the surface and cross-section of prepared products were studied by SEM,FT-IR and DSC.The results showed that the pore structure and morphology can be optimized by adjusting the molecular weight of PLLA,the pressure and temperature of the treated samples to optimize the product structure,and which were suitable for the different biological and medical applications.

关 键 词：超临界CO2 诱导相分离 多孔支架 工艺参数 

分 类 号：R318.08[医药卫生—生物医学工程]