黄芪注射液辅助治疗小儿病毒性心肌炎的临床疗效分析  

Clinical Effects of Adjuvant Treatment by Astragalus Injection on Viral Myocarditis

作　　者：张少卿[1] 杨冠琦[1] 丁晓欢[2] 修婵[1] 赵兴伟[3] ZHANG Shao-qing YANG Guan-qi D XIU Chan ZHAO Xing-wei(Department of paediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning, Shenyang, 110032, China Internal medicine, The Second Aftiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning, Shenyang, 110000, China Department of paediatn＇cs, Central Hospital of Dalian, Liaoning, Dalian, 116033, China)

机构地区：[1]辽宁中医药大学附属医院儿科,辽宁沈阳110032 [2]辽宁中医药大学附属二院内科,辽宁沈阳110000 [3]大连市中心医院儿科,辽宁大连116033

出　　处：《现代生物医学进展》2017年第10期1863-1865,1873,共4页Progress in Modern Biomedicine

基　　金：辽宁省科学技术计划项目(20120620)

摘　　要：目的:探讨黄芪注射液辅助治疗小儿病毒性心肌炎患者的临床疗效及其可能机制。方法:选择我院确诊并治疗的病毒性心肌炎小儿患者72例作受试者,按随机数字表法分为两组,对照组36例予以西医常规治疗,治疗组36例在常规治疗基础上予联合黄芪注射液治疗。观察两组患者的临床疗效,比较患者治疗前后血清肌钙蛋白Ⅰ、乳酸激酶(CK)、乳酸激酶同工(CK-MB)、肿瘤坏死因子-α(TNF-α)、IL-10及IL-6水平的变化。结果:治疗后,对照组总有效率显著低于治疗组(P<0.05);与对照组比较,治疗组治疗后血肌钙蛋白Ⅰ、CK、CK-MB、TNF-α及IL-6水平显著降低,IL-10水平升高,差异具有统计学意义(P<0.05)。结论:黄芪注射液的辅助应用可显著提高小儿病毒性心肌炎患者的临床疗效,这可能与其降低患者血清TNF-α、IL-6水平及提高IL-10水平有关。Objective： To investigate the clinical effects and mechanism of auxiliary application by astragalus injection on the serum levels of cardiac troponin I, IL - 10 and IL - 6 in the children with viral myocarditis. Methods： 72 children with viral myocarditis who were treated in our hospital were selected and randomly divided into two groups, 36 cases in the control group were treated with western medicine routine treatment, while 36 cases in the experiment group were treated on the base of the conventional treatment with astmgalus injection 10 mL, intravenous drip once a day, both groups of patients were continuously treated for 4 weeks. The clinical efficacy, serum cardiac troponin I, lactic acid kinase （CK）, lactic acid kinase co-workers （CK - MB）, TNF -α, IL - 10 and IL - 6 levels were compared between two groups before and after treatment. Results： The total effective rate of control group was lower than that of the experiment group （P 〈 0.05）. Compared with the control group, the serum cardiac troponin I, CK, CK - MB, TNF -α and interleukin family levels of the experiment group statistically reduced （P 〈 0.05）. Conclusion： Astragalus injection auxiliary application could enhance the immunity, and improve the clinical efficacy of children with viral myocarditis, which could be rated to the decrease of serumTNF-α, IL-6 levels and enhancement of serum IL-10 level.

关 键 词：小儿病毒性心肌炎 黄芪注射液 血肌钙蛋白Ⅰ IL-10 IL-6 

分 类 号：R542.21[医药卫生—心血管疾病]