小檗碱抗肿瘤作用机制研究  

Study on anti-tumor mechanism of berberine

作　　者：高世勇[1] 吕春雨[1] 吴爽[1] 林文瀚[1] 于淼[1] 东方[1] 曲中原[1] 许颖[1] 项峥[1] 刘颖杰[1] 辛国松[1] 李钧[1] 陈宁[1] 吴健[1] 马爱英[1] 季宇彬[1] GAO Shi-yong LV Chun-yu WU Shuang LIN Wen-han YU Miao DONG Fang QU Zhong-yuan XU Ying XIANG Zheng LIU Ying-jie XIN Guo-song LI Jun CHEN Ning WU Jian MA Ai-ying JI Yu-bin(Institute of Materia Medica, Life Science and Environment Science Research Center, Harbin University of Commerce, Harbin 150076, China)

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心药物研究所,哈尔滨150076

出　　处：《哈尔滨商业大学学报（自然科学版）》2017年第1期1-3,28,共4页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：黑龙江省高等学校创新团队建设计划项目(2014TD009)

摘　　要：小檗碱具有多种药理作用,其临床应用广泛,具有清热解毒,降血脂,降血糖,抗心力衰竭等药理作用.目前小檗碱抗肿瘤作用成为研究热点,可以通过各种途径和机制抑制肿瘤细胞的发生和发展.将对近年来有关小檗碱在抗肿瘤方面的作用机制进行综述,概括出小檗碱对肿瘤的发生,增殖,凋亡,转移以及肿瘤细胞的分化等方面所发挥的作用,为进一步开发小檗碱在抗肿瘤方面的作用提供可靠依据.Berberine showed many effects, antihypedipidemic effect, pharmacological effects, such as antipyretic and antitoxic hypog｜ycemic activity, resistance to heart failure, et al, which has been applied in clinic. Berberine can inhibit the occurrence and development of tumor through many pathways, which is a hot spot in the present study. In this paper we re- viewed the antitumor mechanism of berberine about the tumor occurrence, proliferation, apoptosis, metastasis of tumor, cell differentiation, which will be helpful in research and devel- opment of berberine on tumor research.

关 键 词：小檗碱 抗肿瘤 机制研究 

分 类 号：R285[医药卫生—中药学]