槲寄生中N-桂皮酰基丁二胺药代动力学研究  

Pharmacokinetic study on N-cinnamoyl putrescine in viscum coloratum nakai

作　　者：孙永慧[1] 李靖[1] 郎悦[2] SUN Yong-hui LI Jing LANG Yue(Academy of Chinese Medicine, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China State Key Laboratory of Pharmaceutical Process New - tech for Chinese Medicine, Jiangsu Kanion Pharmaceutical Co. Ltd. , Lianyungang 222001, China)

机构地区：[1]黑龙江中医药大学中医药研究院,哈尔滨150040 [2]江苏康缘药业股份有限公司,中药制药过程新技术国家重点实验室,江苏连云港222001

出　　处：《哈尔滨商业大学学报（自然科学版）》2017年第1期8-10,共3页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：黑龙江省教育厅科学技术研究项目(12531635)

摘　　要：研究槲寄生中N-桂皮酰基丁二胺在大鼠体内的药代动力学特点.大鼠灌胃给予N-桂皮酰基丁二胺,采集不同时间点的大鼠血浆,用HPLC法检测大鼠血浆中N-桂皮酰基丁二胺的浓度,并用DAS2.0药动学软件进行数据处理,计算药动学参数.N-桂皮酰基丁二胺在大鼠体内的药动学特征符合一室模型,药动学参数分别为:半衰期速率常数T_(1/2)(k_a)=0.343 h,分布半衰期T_(1/2)=1.306 h,达峰时间T_(max)=0.750 h,最大血药浓度C_(max)=1.700μg/m L,表观分布容积V_(1/F)=21.047 L·kg^(-1),口服消除率C_L=11.172 L·h^(-1)·kg^(-1),药时曲线下面积AUC(0-t)=4.129 h·mg·L^(-1).N-桂皮酰基丁二胺口服给药后,吸收和分布均较快,且分布广泛,在血浆中的清除也较快.To study the pharmacokinetic character of N - cinnamoyl putreseine in rats, after the rats were administered by N -cinnamoyl putrescine through ig, HPLC was used to deter- mine the concentration of N - cinnamoyl putrescine in blood plasma at different times, pharmacokinetic software DAS2.0 was used to process the data. N - cinnamoyl putrescine was shown to be one -room distribution model in rats. The main pharmacokinetic parameters of N - cinnamoyl putrescine are as follows ： T1/2 （ ka ） = 0. 343 h, T1/2 = 1. 306 h, Tmax = 0. 750 h, Cmax=1.700 μg · mL-1, V1/r=21.047 L · kg-l, CL=11.172 L· h-1 · kg-l, AUC （0 -t） =4. 129 h · mg·L-1. It indicated that the absorption and distribution of N -cin- namoyl pntrescine was rapid and wide. The distribution was broad and clearance was very quick in the plasma.

关 键 词：N-桂皮酰基丁二胺 药代动力学 HPLC 血药浓度 

分 类 号：R28[医药卫生—中药学]