空气中多环芳烃在人体中的代谢反应及其对吸入性过敏性疾病的影响机制  

Metabolic Response in Human Body to Air Polycyclic Aromatic Hydrocarbons and their Effects on Inhalant Allergic Diseases

作　　者：张昭勇[1] 欧莉莉[2] 罗嘉莹[2] 

机构地区：[1]广州医科大学 [2]广州医科大学附属第一医院广州呼吸疾病研究所

出　　处：《环境卫生学杂志》2017年第1期69-74,共6页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：广州市医药卫生科技项目(20161A011066)

摘　　要：环境因素是从外部影响机体内在平衡的主导因素,很多疾病,特别是对外界环境最敏感的过敏性疾病,不良影响最明显。环境因素影响机体的途径多样,空气中的多环芳烃通过干扰人体内的氧化/抗氧化平衡,使体内发生更多的氧化应激损伤,导致疾病症状恶化。从氧化应激的角度探究空气中的多环芳烃对机体疾病发生发展影响的形式和程度,以及使用环境干预来防止易受环境因素干扰疾病恶化的研究具有重要指导意义。Environmental factors are main factors influencing the internal balance in human body,especially in allergic diseases,which are most sensitive to external environment. Environmental factors affect human body with a diversity of ways,and the way of polycyclic aromatic hydrocarbons is interfering with the balance of oxidation/antioxidation,producing more oxidative stress injuries in the body and leading to deterioration of symptoms. From the point of view of oxidative stress,the research on exploring the type and extent of air polycyclic aromatic hydrocarbons on human diseases,and using environmental intervention to prevent the exacerbation of some diseases caused by environmental factors would have important guiding significance.

关 键 词：氧化应激 环境因素 自由基 

分 类 号：R122[医药卫生—环境卫生学]