抗苗勒管激素、类胰岛素样生长因子1和胰岛素样生长因子结合蛋白1在多囊卵巢综合征诊断中的应用价值  

The diagnostic value of serum AMH, IGF-1 and IGFBP-1 levels in polycystic ovarian syndrome

作　　者：杨海波 

机构地区：[1]浙江省苍南县第二人民医院妇科,325802

出　　处：《中国基层医药》2017年第9期1409-1412,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨血清抗苗勒管激素（AMH）、类胰岛素样生长因子1（IGF-1）和胰岛素样生长因子结合蛋白1（IGFBP-1）水平与多囊卵巢综合征（PCOS）的关系及其临床意义.方法 采用ELISA法检测80例PCOS患者（PCOS组）血清中AMH、IGF-1、IGFBP-1浓度水平,并以80例健康人作为对照组,进行对比分析.结果 PCOS组血清AMH、IGF-1、IGFBP-1水平分别为（10.83±1.88）ng/L、（175.91±17.86） ng/L、（5.23±0.81） ng/L,对照组分别为（3.70±1.01）ng/L、（110.58±12.50） ng/L、（8.16±1.39） ng/L,PCOS组与对照组相比,血清AMH、IGF-1水平升高（t=13.14、26.80,均P＜0.01）,而IGFBP-1水平降低（t=16.28,P＜0.01）;PCOS组中肥胖组血清AMH、IGF-1、IGFBP-1水平分别为（7.18±1.50） ng/L、（200.85±27.78） ng/L、（4.05±0.65） ng/L,非肥胖组分别为（15.52±2.41） ng/L、（143.85±15.61） ng/L、（6.75±0.93）ng/L,肥胖组与非肥胖组相比,血清IGF-1水平升高（t=10.87,P＜0.01）,而AMH和IGFBP-1水平降低（t=18.98、15.27,均P＜0.01）.结论 血清AMH、IGF-1、IGFBP-1可能参与了PCOS的发病过程和肥胖的形成,可能与PCOS的发病机制有关.Objective To explore the relation between serum AMH,IGF-1 and IGFBP-1 levels and polycystic ovarian syndrome （PCOS） and its clinical significance.Methods Serum levels of AMH,IGF-1 and IGFBP-1 were measured by ELISA in 80 patients with PCOS and 80 healthy subjects.Results The levels of serum AMH,IGF-1,IGFBP-1 in PCOS group were （7.18 ± 1.50） ng/L,（200.85 ± 27.78） ng/L,（4.05 ± 0.65） ng/L respectively,which in the control group were （3.70 ± 1.01） ng/L,（110.58 ± 12.50） ng/L,（8.16 ± 1.39） ng/L.The serum levels of AMH,IGF-1 in the PCOS group were significandy higher than those in the control group（t =13.14,26.80,P 〈 0.01）,while the serum level of IGFBP-1 in the PCOS group was significantly lower than that in the control group（t =16.28,P 〈0.01）.The serum levels of AMH,IGF-1,IGFBP-1 in patients with obese group were （7.18 ± 1.50） ng/L,（200.85 ± 27.78） rng/L,（4.05 ± 0.65）ng/ L respectively,which in the non-obese group were （15.52 ± 2.41） ng/L,（143.85 ± 15.61） ng/L,（6.75 ± 0.93） ng/L.The serum level of IGF-1 in the obese group was significantly higher than that in the non-obese group（t =10.87,P 〈0.01）,while the serum levels of AMH and IGFBP-1 in the obese group were significandy lower than those in the non-obese group（t =18.98,15.27,P 〈0.01）.Conclusion Serum AMH,IGF-1 and IGFBP-1 may be involved in the pathogenesis and obesity of PCOS,which may be associated with the pathogenesis of PCOS.

关 键 词：多囊卵巢综合征 抗苗勒管激素 类胰岛素样生长因子1 胰岛素样生长因子结合蛋白1 肥胖症 

分 类 号：R711.75[医药卫生—妇产科学]