溶血磷脂酸及其受体与脑梗死关系的研究现状  

Current study of cerebral infarction and Lysophosphatidic acid and its receptor

作　　者：谷艳霞[1] 王超[1] 张兆辉[1] 

机构地区：[1]武汉大学人民医院神经内科,湖北武汉430060

出　　处：《职业与健康》2017年第4期573-576,共4页Occupation and Health

摘　　要：溶血磷脂酸(LPA)是一种普遍存在的、对多种细胞具有不同生物活性的磷脂介质,它作为细胞外的信号分子通过与6种已知的G蛋白偶联受体(GPCRs):LPA1-LPA6结合介导细胞内的生物作用如细胞存活、增殖、分化、黏附和形态改变。在缺血性脑血管病发生部位LPA水平增高。研究发现LPA及其受体参与脑梗死的发病,影响神经血管单元介导神经损伤。Lysophosphatidic acid（LPA）is a small ubiquitous phospholipid involved in various biologic processes of a range of cell type. LPA signals extracellularly via at least 6 cognate G protein-coupled receptors to mediate cellular processes such as survival,proliferation,differentiation,adhesion and morphology. Elevated LPA levels have been detected in cerebral ischemia.It has been shown LPA and its receptors are implicated in the pathogenesis of cerebral infarction and interfere with components of neurovascular,and mediates nerve damage.

关 键 词：溶血磷脂酸 G-蛋白偶联受体 脑梗死 

分 类 号：R542[医药卫生—心血管疾病]