LDHs生物医学复合材料的制备及其在药物输送和诊疗方面的应用  

The fabrication of layered double hydroxides based bio-materials and their application in theranostic and drug delivery

作　　者：梅旭安 彭刘琪 梁瑞政 卫敏[1] Xu＇an Mei Liuqi Peng Ruizheng Liang Min Wei(State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China)

机构地区：[1]北京化工大学化工资源有效利用国家重点实验室,北京100029

出　　处：《中国科学：化学》2017年第4期431-441,共11页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21601010)资助项目

摘　　要：生命科学是关乎人类健康的重要研究领域.基于无机纳米材料为载体的生物无机材料推动了生命科学的发展.水滑石(LDHs)作为一种二维无机纳米材料,具有层板金属离子种类和比例可调控以及层间可插层的特性,近年来在生物医学领域受到广泛关注.本文重点介绍了水滑石纳米复合材料的物理化学结构、作为基因/药物载体的应用,以及在新型诊疗一体化复合材料领域的应用和优势.此外,通过细胞和活体实验,进一步探讨了水滑石纳米复合材料的细胞输运机制、诊断成像以及肿瘤治疗效果,并展望了水滑石纳米复合材料在生物医学领域的发展前景.With the fast development of bio-related science, theranostic composite materials have recently attracted considerable attention due to their advantages in the combination of diagnosis and treatment. Layered double hydroxides （LDHs） have been widely applied as various multi-functional materials and exhibited great potential in the construction of bio-materials. This review introduces the construction of new hybrid materials based on LDHs host and bio-materials through intercalation assembly. Aiming at fabrication of hybrid materials with superior performances in diagnosis and treatment, we expatiate upon the intercalation structure, the arrangement of guests and host-guest interaction to achieve the synergistic effect of LDHs host and intercalated biomaterials. Moreover, the growing trend and promising new strategies are discussed from the point of view of specific clinical challenges.

关 键 词：水滑石(LDHs) 插层组装 成像治疗 药物输送 生物无机纳米材料 

分 类 号：R318.08[医药卫生—生物医学工程] TB332[医药卫生—基础医学]