云南汉族原发性高血压ACE基因多态性与厄贝沙坦降压疗效相关性  

The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients

作　　者：黄红[1] 陈波[2] 李燕[1] 全胜麟[1] 唐林青 张彤[1] 全晶[1] HUANG Hong CHEN Bo LI Yan QUAN Sheng-lin TANG Lin-qing ZHANG Tong QUAN Jing(Dept. of Gerontology, First People＇s Hospital of Yunnan Province, Kunming Yunncm 650032 Experiment Center for Medical Science Research, Kunming Medical University, Kunming Yunnan 650500 The Second People＇s Hospital of Dehong, Dehong Yunnan 678400, China)

机构地区：[1]云南省第一人民医院内干科,云南昆明650032 [2]昆明医科大学科研实验中心,云南昆明650500 [3]德宏州第二人民医院,云南德宏678400

出　　处：《昆明医科大学学报》2016年第7期40-43,共4页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2013FB202);云南省教育厅科学研究基金资助项目(2013C211);云南省卫生和计划生育委员会内设研究机构科研项目(2016NS201)

摘　　要：目的探讨云南汉族原发性高血压（EH）患者ACE基因多态性与厄贝沙坦降压疗效相关性．方法选择100例1—2级原发性高血压患者，PCR检测基因多态性，厄贝沙坦150mg，每日1次降压治疗4周后评估降压疗效．结果厄贝沙坦降压疗效在不同基因型中具有差异性，降压疗效DD型〉ID型〉II型，差异有统计学意义（P〈0．05）．结论不同基因型对ARB药物治疗反应性具有差异性，基因多态性可能是影响个体对药物治疗反应的遗传因素。Objective To analyze the correlationship of ACE I/D gene polymerphisms with the anti-hypertensive efficacy of irbesartan among essential hypertension （EH） patients in Yunnan han people. Methods One hundred EH patients hypertension were treated with irbesartan 150rag once daily for 4 weeks, and anti-hypertensive efficacy were monitored during the treatment. Results There was a significant difference between anti-hypertensive efficacy of irbesartan among different genotype groups, DD group 〉ID group 〉II group （P 〈 0.05） Conclusions There is different therapy responsiveness in diffenent genotypes. ACE I/D polymorphism may be an important hereditary factor that impacts the efficacy of irbesartan.

关 键 词：云南 汉族 原发性高血压 ACE基因 基因多态性 厄贝沙坦 降压疗效 

分 类 号：R544.1[医药卫生—心血管疾病]