氨溴索对老年慢性阻塞性肺病急性加重期的疗效对比  

The Observation of Clinical Effect of Using Ambroxol in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：胡伟华[1] 肖卫[1] 陈振平[1] 王磊[1] HU Wei-hua XIAO Wei CHEN Zhen-ping WANG Lei(The first People＇s Hospital of Jingzhou Affiliated to Yangtze University, Jingzhou Hubei 434000, Chia)

机构地区：[1]长江大学附属荆州市第一人民医院,湖北荆州434000

出　　处：《昆明医科大学学报》2016年第8期65-67,共3页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(30860286);荆州市医疗卫生科技计划项目(2013-23)

摘　　要：目的比较2种剂量的盐酸氨溴索对老年慢性阻塞性肺病急性加重期的疗效.方法采用随机数字法将2012年5月至2014年5月在荆州市第一人民医院110例老年慢性阻塞性肺病加重期患者分为小剂量组和大剂量组,小剂量组(56例)给予盐酸氨溴索30 mg,2次/d,连续10 d静脉滴注;大剂量组(54例)给予盐酸氨溴索60 mg/次,2次/d,连续10 d静脉滴注;并对2种剂量盐酸氨溴索的临床疗效进行观察.结果大剂量盐酸氨溴索的临床总有效率(85.19%)明显高于小剂量组(75.00%),2组存在差异有统计学意义(P<0.05);在不良反应方面,大剂量盐酸氨溴索的不良反应发生率(4.26%)与小剂量组(2.08%)相比未见统计学差异(P>0.05).结论大剂量盐酸氨溴索对老年慢性阻塞性肺病加重期疗效显著,安全性高.Objective To compare the efficacy of two doses of ambroxol in the treatment of the elderly patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods A hundred and ten cases of the elderly patients with an acute exacerbation of COPD were divided into low-dose group and high-dose group. Low-dose group（56 cases） were given Ambroxol 30 mg, 2 times per day for 10 day and high-dose group（54 cases） were given Ambroxol 60 mg,2 times per day for 10 days.Results The effective rate in high-dose group was significantly higher than that in low-dose group.Conclusion High-dose ambroxol has significant effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease.

关 键 词：盐酸氨溴索 老年 患者慢性阻塞性肺病 急性加重期 疗效 

分 类 号：R563[医药卫生—呼吸系统]