CD11b表达与人工髋关节置换术后无菌性松动的相关性分析  

Analysis of the Correlation between CD11b Expression and Aseptic Loosening

作　　者：杨国曦 陈晓勇[1] 朱锦宇[1] 朱庆生[1] 杨重飞[1] YANG Guo-xi CHEAT Xiao-yong ZHU Jin-yu ZHU Qing-sheng YANG Chong-fei(Orthopedics Department, Xijing Hospital, The Fourth Military Medical University, Xi＇an, Shaanxi, 710032, China)

机构地区：[1]第四军医大学附属西京医院骨一科,陕西西安710032

出　　处：《现代生物医学进展》2017年第11期2046-2049,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81301541)

摘　　要：目的:分析髋关节周围滑膜组织CD11b表达水平与人工髋关节置换术后无菌性松动的相关性。方法:以2006年5月至2016年5月于西京医院接受人工髋关节置换的患者为研究对象,对其髋关节周围滑膜组织进行CD11b免疫组化染色,并随访术后5年和10年无菌性松动的发生情况,通过单因素分析及logistic回归分析讨论CD11b表达与无菌性松动之间的相关性。结果:共300例患者纳入研究,全部获得随访,CD11b表达阳性患者163例,阳性率为54.33%;术后5年松动患者29例,术后5年无菌性松动发生率为9.67%;术后10年无菌性松动患者49例,术后10年无菌性松动发生率为16.33%;单因素分析结果表明CD11b表达阳性患者5年及10年松动率均高于CD11b表达阴性患者(P<0.05);logistic回归分析结果表明CD11b过表达是髋关节置换术后无菌性松动发生的危险因素。结论:髋关节周围滑膜组织CD11b过表达是人工髋关节置换术后无菌性松动发生的危险因素,该分子或可作为无菌性松动的辅助诊断指标及潜在治疗靶点。Objective： To analyze the correlation between CD1 lb expression and aseptic loosening. Methods： CD1 lb of synovial tissue around the hip joint from patients received total hip replacement during 2006 May to 2016 May were immunohistochemical stained, and a follow-up was performed to detect the occurrence of aseptic loosening. Single factor analysis and logistic regression analy- sis was used to investigate the correlation between CD1 lb expression and aseptic loosening occurrence. Results： 300 patients were fol- lowed up; the number ofCD1 lb positive patients was 163, CD1 lb postive ratio was 54.33 %; 29 patients （9.67 %） suffered from aseptic loosening 5 years after operation and 49 patients（16.33%） suffered from aseptic loosening 10 years after operation; the aseptic loosening raio of CD1 lb-positive patients was higher than that of CD1 lb-negative patients （P〈0.05）; logistic regression analysis suggested that CD1 lb over-expression was the risk factor of aseptic loosening. Conclusions： CD1 lb over-expression was the risk factor of aseptic loos- ening and CD1 lb might be an auxiliary diagnosis indicator and potential therapeutic target of aseptic loosening after total hip replace- ment.

关 键 词：CD11B 无菌性松动 相关性分析 

分 类 号：R687[医药卫生—骨科学]