核医学肾动态显像和血清Cys C在评价肾积水患者肾功能中的临床应用  

Clinical Application of Renal Dynamic Imaging and Serum Cystatin C for Evaluation of Renal Function in Patients with Hydronephrosis

作　　者：高波[1] 雷光[1] 翟春红[1] 程实[2] 王蕾[2] GAO Be LEI Guang ZHAI Chun-hong CHENG Shi WANG Lei(Department of Nuclear Medicine, Guang＇anrnen Hospital of China Academy of Chinese Medical Sciences, Beijing, 100053, China Department of Laboratory Medicine, Guang＇anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, 100053, China)

机构地区：[1]中国中医科学院广安门医院核医学科,北京100053 [2]中国中医科学院广安门医院检验科,北京100053

出　　处：《现代生物医学进展》2017年第11期2054-2056,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨核医学肾动态显像和血清胱抑素C(Cys C)在评价肾积水患者肾功能中的临床应用。方法:选择2014年1月至2015年1月我院收治的肾积水患者70例,依据肾积水程度将患者分为轻度积水组(21例)、中度积水组(26例)、重度积水组(23例)三组,选择同期我院体检中心的健康成人20例作为对照组,所有研究对象分别通过肾动态显像和双血浆法测量肾小球率过滤(GFR),分别记为I-GFR和rGFR,采用酶联免疫吸附法和血生化分析仪分别检测血清Cys C和尿素氮(BUN)、血肌酐(SCr)。结果:各组各指标比较差异均有统计学意义(均P<0.05),肾积水患者r-GFR、I-GFR显著低于对照组患者,Cys C、BUN、SCr均显著高于对照组患者,差异有统计学意义(均P<0.05);不同程度患者r-GFR、Cys C和SCr差异有统计学意义(均P<0.05),其中,重度积水组>中度积水组>轻度积水组,差异有统计学意义(均P<0.05);重度积水组I-GFR和BUN均高于轻度积水组和中度积水组,差异有统计学意义(均P<0.05);rGFR和I-GFR与肾积水程度呈负相关(r=-0.967、-0.754,P=0.000、0.000),Cys C、BUN和SCr与肾积水程度呈正相关(r=0.883、0.627、0.671,P=0.000、0.002、0.001)。结论:核医学肾动态显像在评价轻度肾积水患者肾功能时更敏感,而血清Cys C在区分中、重度肾积水患者时更加准确,上述两指标作为替代双血浆法的检测方法在临床上应该互为补充,方能使诊断更加准确。Objective： To investigate the clinical application of renal dynamic imaging and serum Cystatin C for evaluation of re- nal function in patients with hydronephrosis. Methods： 70 patients with hydronephrosis were enrolled from Jan.2014 to Jan.2015, then di- vided into three groups, which were Mild- group （n=21）, Moderate- group （n=26） and Severe- group （n=23）, according to degree of hy- dronephrosis, and 20 healthy subjects were enrolled at same time as control group. All of the subjects were calculated glomerular filtra- tion rate （GFR） by renal dynamic imaging and two-sample method which were recorded as I-GFR and rGFR. Cys C were detected with ELISA kit, blood urea nitrogen （BUN） and serum creatinine （SCr） were detected by automatic biochemistry analyzer. Results： There were significant differences in the indexes of each group （all P〈0.05）, patients with r-GFR and I-GFR in patients with renal water were signifi- cantly lower than those in the control group, Cys C, BUN, SCr were significantly higher than those in the control group, the difference was statistically significant （all P〈0.05）; There were significant differences in r-GFR, Cys C and SCr in patients with different degrees （all P〈0.05）, among them, severe-group〉moderate-group〉mild-group, the difference was statistically significant （all P〈0.05）; The I-GFR and BUN of Severe-group were all higher than those in mild-group and moderate-group, the difference was statistically significant （all P〈0. 05）; rGFR and I-GFR were negatively correlated with the degree of renal water （r=-0.967, -0.754; P=0.000, 0.000）, Cys C, BUN and SCr were positively correlated with the degree ofrenat water （r=0.883, 0.627, 0.671; P=0.000, 0.002, 0.001）. Conclusion： The renal dynamic imaging in the evaluation of renal function in patients with mild hydronephrosis was more sensitive, while Cys C in distinguishing severe and moderate hydronephrosis was more accurate. As the alternative methods for the detection

关 键 词：肾积水 肾动态显像 CYS C 

分 类 号：R445[医药卫生—影像医学与核医学] R692[医药卫生—诊断学]