丹参注射液对晚期重度子痫前期产妇的氧化蛋白产物及血管紧张素Ⅱ的影响分析  

Impact of Danshen injection on oxidation protein products and angiotensin Ⅱ of late puerpera with severe preeclampsia

作　　者：张印星[1] 潘春燕[1] 陈小刚[1] 

机构地区：[1]黄石市中心医院(湖北理工学院附属医院)妇产科,湖北黄石435000

出　　处：《中国性科学》2017年第4期132-135,共4页Chinese Journal of Human Sexuality

基　　金：湖北省重点实验室2014年度开放基金(SB201405)

摘　　要：目的:研究丹参注射液对晚期重度子痫前期产妇的氧化蛋白产物(AOPP)及血管紧张素Ⅱ的影响并作出相关分析。方法:采用抽签法随机选取2013年5月1日至2015年8月1日我院收治的晚期重度子痫前期产妇100进行研究分析,并按照随机数表法随机地分成实验组和对照组各50例。对照组给予每天静脉注射25%硫酸镁注射液的常规治疗,实验组在此基础上每日给予丹参注射液进行治疗。分别对两组患者进行治疗前和治疗后的血浆中AOPP浓度、血管紧张素转化酶(angiotensin converting enzyme,ACE)活性和平均动脉压、平均舒张压的变化进行测定,并统计两组患者在治疗后出现不良反应的例数。结果:治疗前,两组患者的血浆中的AOPP含量和ACE活性比较,无统计学差异(P>0.05)。治疗后,两患者血浆中的AOPP含量和ACE活性均有明显的降低,且观察组AOPP含量和ACE活性均明显低于对照组患者,差异有统计学意义(P<0.05)。治疗前,两组患者的血压指标中平均舒张压和平均动脉压差异不明显,无统计学意义(P>0.05)。治疗后,两组患者的平均舒张压和平均动脉压均明显降低,且观察组的平均舒张压和平均动脉压均明显低于对照组,差异有统计学意义(P<0.05)。两组患者均有低蛋白血症、新生儿黄疸、心肾功能衰竭发生,但二者比较差异并不明显,无统计学意义(P>0.05)。结论:丹参注射液能有效降低晚期重度子痫前期产妇的氧化蛋白产物的含量和抑制血管紧张素Ⅱ的生成,还可以降低患者治疗后不良反应的发生率。Objectives：To study the impact of Danshen injection on oxidation protein products and angiotensinⅡof late puerpera with severe preeclampsia and make a correlation analysis. Methods：100 late puerpera with severe preeclampsia in our hospital from May 1,2013 to August 1,2015 were selected and randomly divided into experimental group（50 cases） and control group（50 cases）. The control group received daily intravenous injections of25% magnesium sulfate injection as conventional treatment,and the experimental group on such basis received Danshen injection treatment. The plasma AOPP concentrations,angiotensin converting enzyme（angiotensin converting enzyme,ACE） activity,mean arterial pressure and mean diastolic blood pressure changes and cases of adverse reactions before treatment and two months after treatment were measured in the two groups. Results：Before treatment,difference in the plasma AOPP content and ACE activity between the two groups was not significant（P〉0. 05）. After treatment,the plasma AOPP content and ACE activity were significantly decreased in both groups,more significant in the observation group than the control group（P〈0. 05）. Before treatment,difference in the mean diastolic blood pressure and mean arterial pressure was not significant between the two groups（P〉0. 05）. After treatment,the mean diastolic and mean arterial pressures were significantly lower in both groups,more significant in the observation group than the control group（P〈0. 05）. The two groups had hypoproteinemia,neonatal jaundice,heart and kidney failure,but without statistically significant difference（P〉0. 05）. Conclusion：Danshen injection can reduce the content of advanced oxidation protein products of late puerpera with severe preeclampsia and inhibit the formation of angiotensin Ⅱeffectively,but also reduce the incidence of adverse reactions in patients after treatment.

关 键 词：重度子痫前期 氧化蛋白产物 血管紧张素Ⅱ 丹参注射液 

分 类 号：R714.25[医药卫生—妇产科学]