山东地区孕妇乙型肝炎感染和免疫状况分析  

Analysis of hepatitis B infection and immune status in pregnant women in Shandong

作　　者：刘义庆[1] 李丽[1] 孙文萍[1] 许丽[2] 邵婧[1] 张炳昌[1] 

机构地区：[1]山东大学附属省立医院临床医学检验部,山东济南250021 [2]山东大学第二医院感染/肝病科,山东济南250033

出　　处：《中国卫生检验杂志》2017年第7期1029-1031,共3页Chinese Journal of Health Laboratory Technology

基　　金：山东省自然科学基金(ZR2016HM52);山东省临床重点专科建设项目(鲁卫医字[2013]26号);山东省医药卫生重点实验室(鲁卫科教国合字[2013]49号)

摘　　要：目的了解山东地区孕妇乙型肝炎病毒感染和免疫状况。方法收集2010年-2015年在山东省立医院孕妇产前检查的血液标本28 910份,用电化学发光法进行乙型肝炎病毒的血清学指标检测。结果 2010年-2015年孕妇HBsAg阳性率呈逐年下降趋势,差异有统计学意义(χ~2=21.589,P<0.01)。随着年龄的增加孕妇HBs Ag的阳性率逐渐增高,差异有统计学意义(χ~2=8.521,P=0.014)。乙型肝炎的感染模式有10种,其中以乙肝小三阳的检出率最高,为60.58%,其次为乙肝大三阳(31.33%)。孕妇中HBs Ab阴性比例为38.20%,弱免疫应答比例为16.97%,高免疫应答比例为44.83%。结论孕妇中存在一定比例的乙型肝炎病毒感染者和易感者。孕前期、孕后期预防乙型肝炎病毒感染和阻断母婴传播,对优生优育,提高人口素质有重要意义。Objective To understand the infection and immune status of hepatitis B virus in pregnant women in Shandong.Methods 28 910 blood samples were collected from pregnant women who came to Shandong Provincial Hospital for prenatal examination during 2010-2015,and the samples were conducted for serological detection of hepatitis B virus by electrochemiluminescence immunoassay（ECLIA）.Results Positive rate of HBsAg in pregnant women showed a yearly decline from 2010 to2015,and the differences were statistically significant（χ^2= 21.589,P〈0.01）.With the increase of age,the positive rate of HBsAg gradually increased,and the differences were statistically significant（χ^2= 8.521,P = 0.014）.We find 10 kinds of hepatitis B infection models,with the highest detection rate of HBsAg ＋ HBe Ab ＋ HBcAb positive as 60.58%,followed by HBsAg ＋ HBe Ag ＋ HBcAb positive rate as 31.33%.The negative ratio of HBs Ab in pregnant women was 38.20%,the proportion of low immune response was 16.97%,and the high proportion of immune response was 44.83%.Conclusion In pregnant women,there is a certain percentage of the hepatitis B virus infected persons and susceptible persons.In late pregnancy,prevention of hepatitis B virus infection and mother to child transmission of eugenics has important significance to improve the quality of the population.

关 键 词：孕妇 乙型肝炎病毒 乙型肝炎表面抗原 乙型肝炎表面抗体 

分 类 号：R512.62[医药卫生—内科学]