耐碳青霉烯类肠杆菌科细菌标本分布及耐药性分析  

Distribution and drug resistance analysis of carbapenem-resistant Enterobacteriaceae

作　　者：贾磊[1] 陆锦琪[1] 马燮峰[1] 刘宇婷[1] 张绮萍[1] 田俊华[1] 

机构地区：[1]浙江省嘉兴市第一医院,浙江嘉兴314000

出　　处：《中国卫生检验杂志》2017年第7期1046-1049,共4页Chinese Journal of Health Laboratory Technology

基　　金：嘉兴市第一医院“壹计划”项目资助课题(2014-YA-29)

摘　　要：目的了解本院2012年1月-2016年6月耐碳青霉烯类肠杆菌科细菌(CRE)的标本分布及药敏情况,为临床治疗CRE提供有效指导意见。方法使用WHONET 5.6软件,回顾性收集2012年1月-2016年6月临床微生物实验室检出的CRE。结果 2012年1月-2016年6月共检出各类CRE 646株,CRE检出率为3.7%。主要的标本分布在痰液、尿液、腹腔液、胆汁等标本中。检出的前5位CRE分别是肺炎克雷伯菌、大肠埃希菌、奇异变形杆菌、阴沟肠杆菌、黏质沙雷菌;这5种细菌对第一代头孢菌素和第二代头孢菌素耐药,对阿米卡星较为敏感。结论 CRE的检出率从2012年-2016年上半年呈现出递增的趋势,CRE的耐药情况较为严重,应采取综合措施防止CRE的大规模流行。Objective To investigate the distribution and susceptibility of carbapenem-resistant Enterobacteriaceae（CRE） from January 2012 to June 2016,so as to provide effective guidance for the clinical treatment of CRE.Methods Using the WHONET5.6 software,we collected the CRE from January 2012 to June 2016 in clinical microbiology laboratory.Results During January2012-June 2016,a total of 646 CRE strains were detected,with the detection rate of 3.7%.The main specimens were sputum,urine and peritoneal fluid.The top 5 detected CREs were respectively Klebsiella pneumoniae,Escherichia coli,Proteus mirabilis,Enterobacter cloacae and Serratia marcescens.These 5 bacteria were resistant to the first generation of cephalosporins and second-generation cephalosporin,and sensitive to amikacin.Conclusion The detection rate of CRE showed an increasing trend from 2012 to 2016,CRE resistance is more serious,so we should take comprehensive measures to prevent the large-scale epidemic of CRE.

关 键 词：耐碳青霉烯类肠杆菌科细菌 耐药性 药敏 

分 类 号：R446.5[医药卫生—诊断学]