Omega-3多不饱和脂肪酸对稳定型心绞痛病人LPPLA2、LDL及脂蛋白a水平影响  

THE EFFECT OF POLYUNSATURATED OMEGA-3 FATTY ACIDS ON LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2,LDL AND LIPOPROTEIN-A IN PATIENTS WITH STABLE ANGINA

作　　者：陈儒[1] 田嘉伟[2] 张文辉 李荣[4] 辛辉[1] CHEN Ru TIAN Jiawei ZHANG Wenhui LI Rong XIN Hui(Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Chin)

机构地区：[1]青岛大学附属医院心内科,山东青岛266003 [2]青岛大学附属医院急诊科 [3]青岛市李村街道社区卫生服务中心 [4]青岛大学附属医院心电图室

出　　处：《青岛大学医学院学报》2017年第1期46-48,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的研究Omega-3多不饱和脂肪酸(n-3PUFAS)对稳定型心绞痛病人低密度脂蛋白(LDL)、脂蛋白相关磷脂酶A2(LPPLA2)及脂蛋白a水平的影响,为n-3PUFAS治疗稳定型心绞痛提供临床依据。方法在我院心内科经冠状动脉造影诊断为稳定型心绞痛的病人80例,随机分为对照组和试验组,每组各40例。两组病人均给予常规抗冠心病治疗,如给予阿司匹林、瑞舒伐他汀,抗高血压治疗如给予美托洛尔。试验组病人在常规抗冠心病治疗的基础上每天给予n-3PUFAS胶囊(汤臣倍健牌鱼油软胶囊)1g治疗,对照组病人在规律抗冠心病治疗的基础上给予相同剂量的安慰剂(大豆油胶囊)治疗,疗程均为3个月。治疗前后采集病人的空腹静脉血,检测LPPLA2、LDL及脂蛋白a的水平。结果治疗后两组病人血清LPPLA2水平均较治疗前明显下降,差异有显著意义(t=3.825、2.115,P<0.05)。两组病人治疗前后血清LPPLA2、LDL差值比较,差异有显著意义(t=2.813、2.813,P<0.05)。两组组内治疗前后血清脂蛋白a及两组治疗前后血清脂蛋白a差值比较,差异无显著意义(P>0.05)。结论 n-3PUFAS可降低稳定型心绞痛病人血液LPPLA2及LDL水平,但对脂蛋白a无明显影响。Objective To investigate the effects of polyunsaturated Omega-3 fatty acids （n-3PUFAS） on lipoprotein-associated phospholipase A2 （LPPA2）, LDL and lipoproteina-A （LPP-A） in patients with stble angina, and provide basis for n- 3PUFAS in the treatment of stable angina. Methods Eighty patients with stable angina confirmed by coronary angiography done in Department of Cardiology in our hospital were selected and evenly randomized to control group and experimental group. Patients in the two groups were given conventional anti-coronary therapy- such as aspirin and rosuvastatin- as well as antihypertensive treatment such as metoprolol. In addition to the above conventional treatment of coronary heart diasese, patients in the experimental group were given n-3PUFAS capsule, 1 g daily, （HEALTH Fish Oil） ; those in the control group were offered the same dose of placebo （soybean oil capsule）. A treatment course was three months for patients in both groups. Fasting venous blood was collec- ted-before and after treatment--to measure the levels of LPPLA2, LDL and LPP-A. Results After treatment, the level of LPPLA2 in both groups declined versus that before treatment, the difference being significant （t = 3. 825,2.115 （ P 〈 0.05）. The differences in LPPLA2 and LDL, before and after treatment, between the two groups were significant （t = 2.813,2.813（P〈0.05）. There was no significant difference in the level of LPP-A in the two group between before and after treatment （P〈0.05）. Conclusion n-3PUFAS fatty acids can reduce the levels of LPPLA2 and LDL, but does not impact LPP-A, in patients with stable an gina.

关 键 词：冠状动脉疾病 脂肪酸类 不饱和 磷脂酶A 脂蛋白类 LDL 

分 类 号：R541.4[医药卫生—心血管疾病]