男性与女性原发性痛风发病特点比较分析  

CHARACTERISTICS OF PRIMARY GOUT IN MEN AND WOMEN:A COMPARATIVE ANALYSIS

作　　者：刘文昭[1] 于民民[2] 田凯华[3] 贾兆通[1] LIU Wenzhao YU Min- rain TIAN Kaihua JIA Zhaotong(Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Chin)

机构地区：[1]青岛大学附属医院内分泌代谢病科,山东青岛266003 [2]青岛市市立医院 [3]青岛大学附属医院胸外科

出　　处：《青岛大学医学院学报》2017年第1期87-90,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨男性与女性原发性痛风发病特点的差异。方法收集2011年1月—2016年9月在我院门诊就诊的原发性痛风病人1 633例,其中男性1 279例,女性354例,比较男性病人和女性病人的发病年龄、体质量指数(BMI)、痛风家族史、血生化指标、首发部位等临床特点及痛风石、肾结石、冠心病、高血压检出率。结果女性组痛风发病年龄大于男性,差异有统计学意义(t=3.450,P<0.05);55岁以后发病人的比例,女性组为72%,而男性组为28%。女性组尿酸水平低于男性组,差异有统计学意义(t=9.997,P<0.05)。女性组BMI及体质量超标或肥胖病人比例低于男性组(t=6.078,χ~2=12.428,P<0.05)。女性组痛风石、肾结石检出率低于男性组,冠心病、高血压检出率高于男性组,差异有统计学意义(χ~2=6.068~22.494,P<0.05)。女性组习惯性饮酒、长期吸烟病人比例低于男性组,差异有统计学意义(χ~2=26.409、26.474,P<0.05)。女性组家族史阳性比例高于男性组,差异有统计学意义(χ~2=13.590,P<0.05)。两组病人痛风均最易首发于第一跖趾关节,男性组首发于第一跖趾关节的病人比例高于女性组,但差异无统计学意义(P>0.05),女性组病人首发于腕关节、手指关节及膝关节的比例高于男性组(χ~2=6.149~29.961,P<0.05),男性组病人首发于足背关节的比例高于女性组(χ~2=23.049,P<0.05)。结论女性痛风病人发病明显晚于男性,较男性病人有更显著的家族遗传倾向;男性痛风病人易并发痛风石、肾结石,女性病人痛风易伴发冠心病、高血压;除第一跖趾关节外,女性和男性痛风病人易首发的关节明显不同。Objective To explore the differences in onset characteristics of primary gout between male and female.Methods Clinical data of 1 633 patients with primary gout-who came to our clinic to see a doctor during January 2011—September 2016-were collected.Among them,1 279 were men and 354 women.Clinical characteristics-such as age,BMI,family history of gout,blood biochemistry,and the first incidence site-and the detection rate of gout stones,kidney stones,coronary heart disease and hypertension between male and female patients were compared. Results The age of onset of gout in female was greater than that in male,the difference was statistically significant（t=3.450,P〈0.05）.The proportion of onset after 55 years old was72%in women,and showed a rising trend with the growth of age,and that was 28%in men,showing a declining trend with age.The levels of uric acid in female patients were lower than that in male patients（t=9.997,P〈0.05）.The proportion of BMI and overweight or obese female patients were lower than that in male patients（t=6.078,χ^2=12.428,P〈0.05）.In female,the detection rates of tophi and renal stone were lower than that in male,while that of coronary heart disease and hypertension were higher（χ^2=6.068,13.988;P〈0.05）.The proportion of habitual drinking and chronic smoking was higher in male patients than that in female（χ^2=26.409,26.474;P〈0.05）.As for positive family history,the proportion was higher in female patients（χ^2=13.590,P〈0.05）.The most common starting position of the onset was the first metatarsophalangeal joint,male were more than female,but the difference was not statistically significant（P〉0.05）.In the female patients,the percentage of the first onset sites of wrist joint,finger joint and knee was higher as compared with the male（χ^2=6.149-29.961,P〈0.05）,and in the male,the percentage of dorsalis pedis being higher（χ^2=23.049,P〈0.05）. Conclusion Age at onset of gout in women is obviously later than men,and there is a more significant fa

关 键 词：痛风 性别特性 疾病特征 

分 类 号：R589.7[医药卫生—内分泌]