血清中亚甲基四氢叶酸还原酶活性与白癜风临床特征相关性研究  

Correlation between serum MTHFR activity and clinical features of the patients with vitiligo

作　　者：陈佳希[1] 易秀莉[1] 李春英[1] 高天文[1] 

机构地区：[1]第四军医大学西京皮肤医院,西安710032

出　　处：《中国麻风皮肤病杂志》2017年第4期202-204,共3页China Journal of Leprosy and Skin Diseases

基　　金：西京医院助推项目(编号:XJZT15M15)

摘　　要：目的:明确白癜风患者血清中亚甲基四氢叶酸还原酶(MTHFR)活性与白癜风临床特征间的关系。方法:选择性别年龄相匹配的白癜风患者及健康对照各90例,采用ELISA法检测血清中MTHFR活性。结果:白癜风患者血清中MTHFR活性为(332.77±92.85)U/L,显著低于对照组的(403.66±96.56)U/L,(P<0.0001)。静止期、进展期及快速进展期患者血清中MTHFR活性呈逐级降低趋势。MTHFR活性在患者性别、家族史、病程等方面无显著差异。结论:白癜风患者血清中MTHFR活性降低可能与白癜风疾病发展相关。Objective：To determine the correlation between the serum methylenetetrahydrofolate reductase （MTHFR） activity and clinical features of the patients with vitiligo.Methods：The MTHFR activity was detected by enzyme-linked immunosorbent assay （ELISA） in 90 patients with vitiligo and 90 controls with matched age and sex.Results：The mean level of MTHFR was 332.77±92.85 U/L in vitiligo, which was lower than that in controls （403.66±96.56 U/L）, （P〈0.0001）.The level of MTHFR activity in stable vitiligo, progressive vitiligo and rapid progressive vitiligo was decreased in a descending manner.There was no significant difference of MTHFR activity in sex, family history and duration of the disease.Conclusion：Reduction of MTHFR activity may be associated with the development of vitiligo.

关 键 词：白癜风 亚甲基四氢叶酸还原酶 活性 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]