苦参素联合抗组胺药治疗慢性荨麻疹疗效的Meta分析  

Meta-analysis of the efficacy of the oxymatrine combined with antihistamines in the treatment of chronic urticaria

作　　者：徐学琴[1] 刘晓蕙[1] 孙春阳[1] 王瑾瑾[1] 裴兰英[1] 马晓梅[1] 刘颖[1] 杨梦利[1] 闫国立[1] 

机构地区：[1]河南中医药大学基础医学院,河南郑州450046

出　　处：《中国麻风皮肤病杂志》2017年第4期216-219,共4页China Journal of Leprosy and Skin Diseases

摘　　要：目的:评价苦参素联合抗组胺药治疗慢性荨麻疹的疗效及不良反应。方法:检索中国知网、万方、维普、Pubmed、EMbase及Cochrane library等数据库,筛选符合标准的文献,采用RevM an 4.2进行Meta分析。结果:共纳入14篇文献,入选文献发表偏倚较小,无明显异质性(P=0.34)。Meta分析结果显示,苦参素联合抗组胺药组与单用抗组胺药组比较,有效率高[P<0.00001,RR=1.40,95%CI(1.30~1.51)],复发率低[P<0.00001,RR=0.19,95%CI(0.10-0.37)]。结论:苦参素联合抗组胺药治疗慢性荨麻疹疗效优于单用抗组胺药。Objective：To assess the efficacy of the oxymatrine combined with antihistamines in the treatment of chronic urticaria.Methods：The articles about the oxymatrine combined with antihistamines for treating chronic urticaria were searched in CNKI, WANGFANG database, VIP database, Pubmed, EMbase and Cochrane library.The Meta-analysis was performed by Review Manager 4.2 software.Results：A total of 14 researches were included, with small bias and no heterogeneous （P=0.25）.The results of meta-analyses showed that compared with the group of antihistamines alone, the effective rate in the group of oxymatrine combined with antihistamines was higher （P〈0.00001,RR=1.40, 95% CI（1.30-1.51）） and the recurrence rate was lower （P〈0.00001, RR=0.19,95% CI（0.10-0.37））.Conclusion：Oxymatrine combined with antihistamines was more effective than antihistamines alone in the treatment of chronic urticaria.

关 键 词：苦参素 抗组胺药 慢性荨麻疹 META分析 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]